{"id":"W2970978182","doi":"10.1007/978-981-13-8367-0_14","title":"Heteroplasmy Shifting as Therapy for Mitochondrial Disorders","year":2019,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Heteroplasmy; Mitochondrial DNA; Mitochondrial disease; Nuclease; Human mitochondrial genetics; Genetics; Disease; Biology; Medicine; DNA; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007794162,0.001064903,0.001915888,0.001583965,0.000271273,0.0009804888,0.001195007,0.001540339,0.00333148],"category_scores_gemma":[0.0009237076,0.000229554,0.0005454401,0.001364826,0.0007135464,0.0009772247,0.0007477311,0.002861968,0.001773357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006285141,"about_ca_system_score_gemma":0.0006345445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006327427,"about_ca_topic_score_gemma":0.001388237,"domain_scores_codex":[0.9998022,0.00004856056,0.00002795767,0.00004145548,0.0000578535,0.00002207053],"domain_scores_gemma":[0.9997249,0.000179533,0.00003135148,0.000009385165,0.00003619292,0.00001857287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001634059,0.0001216669,0.00007689916,0.01079901,0.0001101273,0.0002622074,0.00003394988,0.0003860333,0.001267363,0.005402422,0.03279902,0.948578],"study_design_scores_gemma":[0.0001342652,0.0002021884,0.0005859439,0.004309332,0.0002507821,0.001766271,0.00004269413,0.0001942398,0.0007331902,0.005518425,0.9862339,0.00002878536],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006546285,0.9987599,0.0001862142,0.0002243864,0.0002447327,0.000004126937,0.00001041792,0.000007181419,0.0004976019],"genre_scores_gemma":[0.0009833457,0.9971766,0.0003529557,0.0004564886,0.000357614,0.00001406863,0.00003079044,0.000003736501,0.0006243353],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00333148,"threshold_uncertainty_score":0.01114494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05171843733605434,"score_gpt":0.4091049654947612,"score_spread":0.3573865281587069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}