{"id":"W2971062334","doi":"10.1128/jvi.01380-19","title":"Breast Tumor-Associated Metalloproteases Restrict Reovirus Oncolysis by Cleaving the σ1 Cell Attachment Protein and Can Be Overcome by Mutation of σ1","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canada Foundation for Innovation; Canada Research Chairs; Government of Canada; Alberta Innovates - Health Solutions; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Metalloproteinase; Mutation; Virology; Protease; Cell; Cell biology; Cancer research; Matrix metalloproteinase; Genetics; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511932,0.0002865854,0.0001821239,0.000106199,0.00009558074,0.000287727,0.0001790348,0.0002284422,0.001629576],"category_scores_gemma":[0.0001698821,0.00006806247,0.0002463186,0.00005992763,0.0001662219,0.0001805052,0.0001391373,0.0003893556,0.0004394508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889983,"about_ca_system_score_gemma":0.0001477269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006320776,"about_ca_topic_score_gemma":0.0008441432,"domain_scores_codex":[0.9998846,0.00001771781,0.000008141381,0.00002019012,0.00002895556,0.00004042735],"domain_scores_gemma":[0.9998817,0.00002970791,0.00003613607,0.00001903948,0.00001490759,0.00001845926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003564835,0.000008484331,0.0001350922,0.00001286803,0.000002678486,0.00002800522,0.000006923679,0.00003315708,0.9986548,0.00007616647,0.00002151741,0.0009847202],"study_design_scores_gemma":[0.000003385827,0.00007647697,0.0008615069,0.000001748251,0.000004470622,0.0002232397,0.00001096063,0.0001955204,0.9971797,0.00003865399,0.001402794,0.000001593519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849337,0.002456051,0.008935831,0.0001984663,0.00003905365,0.00004097903,0.0003085266,0.00009827585,0.002989132],"genre_scores_gemma":[0.9939545,0.0006182382,0.002665787,0.00004236154,0.000004763574,0.00001300021,0.0002547278,0.00002281397,0.002423876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629576,"threshold_uncertainty_score":0.005451441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005566898161075525,"score_gpt":0.2550477401132525,"score_spread":0.249480841952177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}