{"id":"W2971123857","doi":"10.1021/acsomega.9b02305","title":"DNA G-Quadruplexes Activate Heme for Robust Catalysis of Carbene Transfer Reactions","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Simon Fraser University","keywords":"Chemistry; Heme; Deoxyribozyme; DNA; Stereochemistry; Hemin; Catalysis; Guanine; G-quadruplex; Combinatorial chemistry; Photochemistry; Biochemistry; Nucleotide; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138194,0.0001380229,0.0002221854,0.00007135205,0.00004855022,0.00000899411,0.0001301164,0.0001409468,0.000001392614],"category_scores_gemma":[0.00003826273,0.0001201247,0.0001982235,0.000158381,0.0000555388,0.000006637759,0.00002895736,0.00005410822,0.000001851523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001246514,"about_ca_system_score_gemma":0.00002716017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004472162,"about_ca_topic_score_gemma":0.0000537398,"domain_scores_codex":[0.9991874,0.0000180418,0.0002230252,0.0003078322,0.00008165147,0.0001820749],"domain_scores_gemma":[0.9993243,0.00001798698,0.00006542732,0.0004203299,0.000132366,0.00003964934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007312171,0.00005576395,0.0003618195,0.00003035214,0.0001422294,2.024357e-7,0.00001201278,0.00006584551,0.9977338,0.00008186803,0.0002409759,0.001202032],"study_design_scores_gemma":[0.0002688747,0.0001851585,0.0001871708,0.00001381324,0.000079668,0.000003106284,0.00005918849,0.00006405158,0.9829243,0.0000610122,0.01599493,0.0001587493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931769,0.00009832312,0.005868435,0.0001227759,0.0000460977,0.0002043931,0.00006571012,0.00002801922,0.0003893233],"genre_scores_gemma":[0.9925998,0.0001457205,0.005095021,0.00007036624,0.00007778777,0.00001719111,0.0003005092,0.00002188588,0.001671713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01575396,"threshold_uncertainty_score":0.4898545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234421754417736,"score_gpt":0.2574895234371505,"score_spread":0.2451453058929731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}