{"id":"W2971123857","doi":"10.1021/acsomega.9b02305","title":"DNA G-Quadruplexes Activate Heme for Robust Catalysis of Carbene Transfer Reactions","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Simon Fraser University","keywords":"Chemistry; Heme; Deoxyribozyme; DNA; Stereochemistry; Hemin; Catalysis; Guanine; G-quadruplex; Combinatorial chemistry; Photochemistry; Biochemistry; Nucleotide; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545293,0.0001768159,0.000101978,0.00009224891,0.00006572955,0.0001862386,0.0002015598,0.0002267578,0.001449259],"category_scores_gemma":[0.0002142211,0.0001003985,0.0000832268,0.0000677996,0.0001741062,0.0001638614,0.0001581547,0.0003457318,0.000254233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244415,"about_ca_system_score_gemma":0.0001047751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002837754,"about_ca_topic_score_gemma":0.0005171992,"domain_scores_codex":[0.999891,0.00001880543,0.000006147927,0.00003424065,0.0000289946,0.00002070263],"domain_scores_gemma":[0.9999293,0.00002394604,0.00001516935,0.000006282986,0.000008138313,0.00001721114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003294525,0.0000138685,0.00003796868,0.00002090071,0.000002115183,0.00002197389,0.00002014954,0.0001320908,0.9983145,0.0002464843,0.00004243908,0.001114521],"study_design_scores_gemma":[0.00001454692,0.00008779218,0.000188152,0.000001709068,0.000001913332,0.00003026275,0.000006067269,0.001297654,0.997649,0.00005989287,0.0006606088,0.000002392694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913186,0.0002724578,0.006478353,0.00008121062,0.00002091004,0.00003287103,0.00005783754,0.0001417533,0.001595953],"genre_scores_gemma":[0.9957407,0.0000879261,0.002480313,0.00002593539,0.000003489487,0.00001260477,0.00005868782,0.00001744581,0.00157302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449259,"threshold_uncertainty_score":0.004848242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234421754417736,"score_gpt":0.2574895234371505,"score_spread":0.2451453058929731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}