{"id":"W2971134660","doi":"10.1101/19005132","title":"Clinical benefits and adverse effects of genetically-elevated free testosterone levels: a Mendelian randomization analysis","year":2019,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; Hamilton Health Sciences; McMaster University; Population Health Research Institute; Thrombosis and Atherosclerosis Research Institute; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; McMaster University; Sanofi","keywords":"Mendelian randomization; Medicine; Testosterone (patch); Adverse effect; Prostate cancer; Internal medicine; Randomized controlled trial; Statistical significance; Genotype; Biology; Genetic variants; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03769039,0.001486225,0.002698699,0.001960348,0.0005102431,0.0009792709,0.00147659,0.001532432,0.0078547],"category_scores_gemma":[0.05706668,0.0005575558,0.007201076,0.0011586,0.001355728,0.0006523242,0.0009204781,0.001174036,0.0003902395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007424049,"about_ca_system_score_gemma":0.001143165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002495016,"about_ca_topic_score_gemma":0.001149676,"domain_scores_codex":[0.9281832,0.05943503,0.002290176,0.006006269,0.00306134,0.00102403],"domain_scores_gemma":[0.9372004,0.05103998,0.004695469,0.005632758,0.0009534135,0.0004779645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2063509,0.002000529,0.4544149,0.002866092,0.1301998,0.006261474,0.0008651462,0.02103608,0.01624964,0.02586748,0.006544354,0.1273435],"study_design_scores_gemma":[0.04656381,0.03238814,0.3834433,0.0006809442,0.1113656,0.008446069,0.0004765281,0.3628351,0.008333467,0.03569736,0.009224582,0.0005451135],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8653112,0.003070439,0.1236328,0.0007746806,0.0002818755,0.002581051,0.001740211,0.000624005,0.001983747],"genre_scores_gemma":[0.9709722,0.0002715788,0.02618165,0.0002487965,0.00006297614,0.001089916,0.0003943076,0.0000365116,0.0007420562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03769039,"threshold_uncertainty_score":0.1993282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03860639852723211,"score_gpt":0.3098716469651201,"score_spread":0.271265248437888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}