{"id":"W2971202256","doi":"10.1126/scitranslmed.aav6221","title":"Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Deutsche Forschungsgemeinschaft; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Meso Scale Diagnostics; Cure Alzheimer's Fund; Janssen Alzheimer Immunotherapy Research And Development; European Commission; National Institute on Aging; Alzheimer's Association","keywords":"Cognitive decline; Cerebrospinal fluid; TREM2; Disease; Medicine; Alzheimer's disease; Internal medicine; Cognition; Dementia; Neuroscience; Psychology; Psychiatry; Microglia; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07109105448032409,"score_gpt":0.3474458730825199,"score_spread":0.2763548186021958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}