{"id":"W2971293632","doi":"10.1261/rna.070391.119","title":"On the emergence of structural complexity in RNA replicators","year":2019,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Institut national de recherche en informatique et en automatique (INRIA)","keywords":"Biology; RNA; Ribozyme; Computational biology; Nucleic acid structure; Mechanism (biology); Sequence (biology); Evolutionary biology; Replication (statistics); GC-content; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004483735,0.0002339328,0.0003745795,0.0006325353,0.0004744738,0.0009625812,0.000397049,0.0005495326,0.0007673011],"category_scores_gemma":[0.002551818,0.0002410592,0.0004438554,0.0002639254,0.001097869,0.001225663,0.0004526506,0.0004921124,0.00008473295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000466357,"about_ca_system_score_gemma":0.0001966464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112383,"about_ca_topic_score_gemma":0.0009788139,"domain_scores_codex":[0.9999005,0.00003735638,0.000004197266,0.00002132658,0.00001873649,0.00001792151],"domain_scores_gemma":[0.9991989,0.000573881,0.00008885726,0.00004988231,0.00003227685,0.00005631674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001338443,0.00008029174,0.01380074,0.0001071239,0.00007591915,0.0003838484,0.0002494138,0.9077837,0.02161708,0.04689721,0.0002106913,0.008660137],"study_design_scores_gemma":[0.00001238844,0.00005145764,0.005901198,0.00001288503,0.0000170772,0.00006412752,0.00006409555,0.9587598,0.002178303,0.03266,0.000263777,0.0000148021],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800254,0.000209479,0.01772323,0.0002211691,0.000004770514,0.00001032414,0.00005011287,0.00005522935,0.001700267],"genre_scores_gemma":[0.9956657,0.0001251946,0.003939008,0.00001473431,0.00000479805,0.00001030538,0.00003645132,0.00001599283,0.0001878442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112383,"threshold_uncertainty_score":0.003383696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423915882443883,"score_gpt":0.2643081987941175,"score_spread":0.2400690399696787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}