{"id":"W2971320602","doi":"10.1002/med.21632","title":"Targeting B7‐1 in immunotherapy","year":2019,"lang":"en","type":"review","venue":"Medicinal Research Reviews","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"CD80; CD28; Cytotoxic T cell; Immunotherapy; Immune system; Cancer immunotherapy; T cell; Antigen; Biology; Immunology; CD86; Immunological synapse; Co-stimulation; Autoimmunity; Peripheral tolerance; Monoclonal antibody; Cell biology; T-cell receptor; Antibody; CD40; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003219626,0.0005875679,0.0006926272,0.001435285,0.0001812637,0.000642778,0.0004717,0.0008482812,0.003691758],"category_scores_gemma":[0.0002503306,0.0001905806,0.0003254144,0.001027064,0.0002717538,0.0007757783,0.0004952094,0.001670494,0.002943242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004552912,"about_ca_system_score_gemma":0.0006937112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006124209,"about_ca_topic_score_gemma":0.001059756,"domain_scores_codex":[0.9998938,0.00001935366,0.00001183545,0.0000170924,0.00004388367,0.00001406844],"domain_scores_gemma":[0.9999309,0.00002683486,0.00001026174,0.000002291244,0.000020551,0.000009230836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007570595,0.00008569589,0.0001180247,0.01177459,0.00006050761,0.0001928393,0.00004795309,0.0003946818,0.00734549,0.006755128,0.03062198,0.9425274],"study_design_scores_gemma":[0.00001403469,0.00008244907,0.0002714541,0.001507949,0.00004522845,0.0006933833,0.00002067606,0.00009515621,0.001074495,0.001630527,0.9945543,0.00001032275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00022038,0.9971717,0.0002195388,0.0002785521,0.0002998688,0.000006240196,0.00001672424,0.00001239637,0.001774627],"genre_scores_gemma":[0.001360035,0.9961147,0.0003463289,0.0003003866,0.0002125304,0.00001001597,0.00003902816,0.00000232776,0.001614622],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003691758,"threshold_uncertainty_score":0.0123502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3734383938238347,"score_gpt":0.5411864163707715,"score_spread":0.1677480225469368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}