{"id":"W2971320602","doi":"10.1002/med.21632","title":"Targeting B7‐1 in immunotherapy","year":2019,"lang":"en","type":"review","venue":"Medicinal Research Reviews","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"CD80; CD28; Cytotoxic T cell; Immunotherapy; Immune system; Cancer immunotherapy; T cell; Antigen; Biology; Immunology; CD86; Immunological synapse; Co-stimulation; Autoimmunity; Peripheral tolerance; Monoclonal antibody; Cell biology; T-cell receptor; Antibody; CD40; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.01654979,0.0006478512,0.005277764,0.001346752,0.0001098629,0.00004752264,0.0006988106,0.0005239321,0.002257382],"category_scores_gemma":[0.001608645,0.0004005626,0.001171858,0.002477726,0.0003613397,0.00008430861,0.000136119,0.003224115,0.002049033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001243614,"about_ca_system_score_gemma":0.001627015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003290043,"about_ca_topic_score_gemma":0.00002163901,"domain_scores_codex":[0.9917949,0.002232125,0.002221215,0.0009121958,0.001627641,0.001211864],"domain_scores_gemma":[0.9969085,0.0009052492,0.0004586602,0.001273911,0.0001953063,0.0002583373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002353778,0.0001041051,0.00002287463,0.06102704,0.0001346103,0.0001486721,0.00008181262,8.62911e-9,0.0000203936,0.00001580353,0.0262428,0.9119665],"study_design_scores_gemma":[0.001182938,0.0005617538,0.0000142397,0.1306053,0.00017144,0.0001418634,0.00003993565,0.000002390557,6.422555e-7,0.000008591835,0.8669848,0.000286016],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002291512,0.9854863,0.00001063514,0.000319579,0.0004858937,0.007076422,0.000008461651,0.00002892891,0.006581494],"genre_scores_gemma":[8.869559e-7,0.9897386,0.0001780931,0.0003516233,0.0007831988,0.000843049,0.0001604397,0.0001293572,0.007814715],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9116805,"threshold_uncertainty_score":0.9998446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3734383938238347,"score_gpt":0.5411864163707715,"score_spread":0.1677480225469368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}