{"id":"W2971350408","doi":"10.1021/acs.chemrestox.9b00291","title":"Computational Insight into the Differential Mutagenic Patterns of O-Methylthymine Lesions","year":2019,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; University of Lethbridge","keywords":"Chemistry; Stereochemistry; DNA polymerase; Thymine; Polymerase; DNA replication; Hydrogen bond; DNA damage; DNA; AP site; Biophysics; Biochemistry; Biology; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005273902,0.00008770785,0.0001495934,0.0000821576,0.00004074312,0.000009449168,0.0003188434,0.0002133169,0.0001565795],"category_scores_gemma":[0.0003037871,0.00006648869,0.00006304854,0.0001773866,0.0001946613,0.000002221008,0.0003361605,0.0002992242,0.00001862717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003514386,"about_ca_system_score_gemma":0.0001284878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000382992,"about_ca_topic_score_gemma":0.00004013738,"domain_scores_codex":[0.9986097,0.000273558,0.0002623977,0.0002945035,0.0002752002,0.0002846451],"domain_scores_gemma":[0.9991159,0.0003306824,0.00004873184,0.0002910897,0.0001449274,0.00006869548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007241961,0.0001264831,0.01041602,0.00002533792,0.00001564873,0.000001341693,0.0001501085,0.0002321319,0.9845237,0.0005595388,0.00003319243,0.003844033],"study_design_scores_gemma":[0.0006474632,0.0003236095,0.01759366,0.00001370441,0.000003043535,0.000001162784,0.00006827654,0.0007339937,0.9740364,0.002420517,0.004069423,0.00008872302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997205,0.0006202884,0.0005007249,0.0006751311,0.00009463169,0.0002681616,0.000006808428,0.000002517633,0.0006267363],"genre_scores_gemma":[0.9990281,0.0002253333,0.0002506161,0.00004360767,0.0001001307,0.00003300926,0.0001149398,0.00001210392,0.0001921825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01048732,"threshold_uncertainty_score":0.271133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04237754562895,"score_gpt":0.3700087514706404,"score_spread":0.3276312058416904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}