{"id":"W2971378013","doi":"10.1038/s41467-019-11979-z","title":"A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Alliance Française contre les Maladies Parasitaires; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche; National Science Foundation","keywords":"Rhoptry; Biology; Toxoplasma gondii; Apicomplexa; Cell biology; Exocytosis; Intracellular parasite; Plasmodium (life cycle); Dense granule; Secretion; Plasmodium falciparum; Parasite hosting; Virology; Intracellular; Immunology; Malaria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000946063,0.0001560996,0.0001413481,0.0001135605,0.0001200502,0.0001739411,0.00009511314,0.0001460766,0.0004226966],"category_scores_gemma":[0.0001129748,0.00009632573,0.000118754,0.00007094521,0.0001538678,0.0001153488,0.0001520388,0.0002405169,0.0002716864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181905,"about_ca_system_score_gemma":0.0001553951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759132,"about_ca_topic_score_gemma":0.000483731,"domain_scores_codex":[0.9999232,0.00001949001,0.000005421242,0.00001147618,0.00002488436,0.00001556268],"domain_scores_gemma":[0.9999467,0.000009114412,0.00001404962,0.000005826696,0.000007353042,0.00001690441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004923137,0.000005435633,0.0001612787,0.00001479456,0.000001073986,0.0000518859,0.000007085387,0.00003013914,0.9991699,0.00006744962,0.0000177143,0.0004240874],"study_design_scores_gemma":[0.0000222871,0.0001923154,0.01835885,0.000006315281,0.00001094656,0.0008927353,0.0000415205,0.00219118,0.9756301,0.0001279402,0.002521439,0.000004359828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962482,0.0005905384,0.001646692,0.00006621611,0.000006642682,0.00001333076,0.0001037835,0.00002957574,0.001295087],"genre_scores_gemma":[0.9956998,0.0004341882,0.001979672,0.00003351155,0.000004445416,0.00002100903,0.0003747939,0.00001281274,0.001439898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004226966,"threshold_uncertainty_score":0.001414001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807060642744895,"score_gpt":0.2929648680811521,"score_spread":0.2748942616537031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}