{"id":"W2971378013","doi":"10.1038/s41467-019-11979-z","title":"A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Alliance Française contre les Maladies Parasitaires; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche; National Science Foundation","keywords":"Rhoptry; Biology; Toxoplasma gondii; Apicomplexa; Cell biology; Exocytosis; Intracellular parasite; Plasmodium (life cycle); Dense granule; Secretion; Plasmodium falciparum; Parasite hosting; Virology; Intracellular; Immunology; Malaria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004269323,0.0002075206,0.0003319928,0.0002996597,0.0003824191,0.00004296876,0.0005961881,0.0005573028,0.00004237764],"category_scores_gemma":[0.0005671469,0.0001845552,0.00003766809,0.0002857345,0.0004362693,0.0002236527,0.001221358,0.00175104,0.0002062042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005169618,"about_ca_system_score_gemma":0.00005646914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004569316,"about_ca_topic_score_gemma":0.001347765,"domain_scores_codex":[0.9985243,0.0003595507,0.0002751958,0.0003645825,0.00006173387,0.0004146425],"domain_scores_gemma":[0.9978856,0.001011328,0.0001052398,0.0008946089,0.00006003071,0.00004313028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001244856,0.0002393765,0.4678943,0.00009728919,0.0001516049,0.000001744731,0.001806424,8.262927e-7,0.5147119,0.01172492,0.001761914,0.001485251],"study_design_scores_gemma":[0.008069894,0.000701749,0.5862605,0.0010529,0.00009862303,0.0001731976,0.005193589,0.000177781,0.1910371,0.001072495,0.2046246,0.001537552],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745139,0.01785976,5.97022e-7,0.004842359,0.0001531646,0.0008428897,0.00008656953,0.00006521174,0.001635537],"genre_scores_gemma":[0.9935796,0.003396446,0.0005779198,0.00006578941,0.00001071996,0.0002037945,0.0002083018,0.00001962938,0.001937772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3236748,"threshold_uncertainty_score":0.7607496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807060642744895,"score_gpt":0.2929648680811521,"score_spread":0.2748942616537031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}