{"id":"W2971382867","doi":"10.1186/s12874-019-0823-8","title":"Integrating expert opinion with clinical trial data to extrapolate long-term survival: a case study of CAR-T therapy for children and young adults with relapsed or refractory acute lymphoblastic leukemia","year":2019,"lang":"en","type":"article","venue":"BMC Medical Research Methodology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Refractory (planetary science); Lymphoblastic Leukemia; Pediatrics; Expert opinion; Young adult; Clinical trial; Term (time); Leukemia; Oncology; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03667032,0.0003946427,0.00179329,0.0005641148,0.0001689449,0.00004630913,0.000993931,0.0005398434,0.0007370544],"category_scores_gemma":[0.03106885,0.000224341,0.0001123621,0.0007876318,0.0009058011,0.0001482078,0.0007197771,0.001749272,0.000005307905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408356,"about_ca_system_score_gemma":0.005480793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005555432,"about_ca_topic_score_gemma":0.01118065,"domain_scores_codex":[0.9806823,0.0125446,0.001260599,0.001705278,0.00271162,0.001095655],"domain_scores_gemma":[0.947708,0.04783482,0.0002528687,0.002144471,0.0008321916,0.001227638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6928522,0.001587216,0.1069895,0.0002292694,0.001211967,0.001616695,0.004107241,7.186915e-7,0.003116213,0.00001044319,0.0002308156,0.1880477],"study_design_scores_gemma":[0.53942,0.2962108,0.1271288,0.002315009,0.0002358896,0.01111554,0.01899116,0.002836152,0.0004474306,0.00001087257,0.0004850065,0.0008033215],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765738,0.0004693113,0.01164756,0.0001854613,0.0004946779,0.01050882,0.00004269734,0.00004712699,0.00003059312],"genre_scores_gemma":[0.9507347,0.003675237,0.04129876,0.0001855533,0.001539556,0.0009129354,0.000253291,0.0002132429,0.001186689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2946236,"threshold_uncertainty_score":0.9919506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5060217933686972,"score_gpt":0.5783941496880564,"score_spread":0.07237235631935912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}