{"id":"W2971389236","doi":"10.1186/s13041-019-0494-8","title":"Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels","year":2019,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Alberta Children's Hospital; University of Calgary; University of Victoria","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Scottish Rite Charitable Foundation of Canada; Michael Smith Health Research BC; University of Victoria","keywords":"Ankyrin; HEK 293 cells; Intracellular; Cell biology; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002157921,0.0001996197,0.0001690776,0.00004538954,0.00006375004,0.00006054843,0.00008382374,0.0001963095,0.00007835819],"category_scores_gemma":[0.00004588496,0.0002018802,0.00005046761,0.00007322305,0.00005880939,0.000008553789,0.0001384861,0.00009261906,0.0000188081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009319136,"about_ca_system_score_gemma":0.00002603476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000167234,"about_ca_topic_score_gemma":0.000006266239,"domain_scores_codex":[0.9988251,0.0001110023,0.0001815428,0.0004933508,0.0001460006,0.0002429903],"domain_scores_gemma":[0.9994511,0.00001164814,0.00006334858,0.0003056781,0.00005247217,0.000115776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004387854,0.0000258248,0.001588779,0.00002543137,0.00004634905,0.000009539566,0.00005307041,0.0006281086,0.9948785,0.0004934362,0.0002464675,0.001960628],"study_design_scores_gemma":[0.002706917,0.0003806745,0.05462676,0.0000356447,0.00003516022,0.0001006845,0.00008045857,0.01774657,0.9143007,0.0006419999,0.008643042,0.0007014121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796447,0.0005028719,0.01826486,0.0006341633,0.0002709566,0.000278042,0.00001773915,0.00002060154,0.0003660642],"genre_scores_gemma":[0.9958104,0.00003404983,0.0005474523,0.0005007609,0.00008295895,0.00000390755,0.0001047027,0.00003394948,0.002881829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08057781,"threshold_uncertainty_score":0.8232434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007328603985731545,"score_gpt":0.2130646020909162,"score_spread":0.2057359981051847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}