{"id":"W2971404000","doi":"10.33380//2305-2066-2019-8-3-91-100","title":"A Comparative Parallel Study of Pharmacokinetics and Immunogenicity Following Single Intravenous Administration of Bevacizumab Biosimilar RPH-001 (Manufactured by R-Pharm Group, Russia) and Avastin® (Manufactured by F. Hoffmann-La Roche Ltd., Switzerland) in Healthy Male Volunteers","year":2019,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Bevacizumab; Medicine; Pharmacokinetics; Immunogenicity; Biosimilar; Pharmacology; Antibody; Internal medicine; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007116369,0.0003400944,0.000714556,0.0001277429,0.0001069801,0.00003474948,0.0001614674,0.0002670574,0.00005311493],"category_scores_gemma":[0.0000285955,0.0003057239,0.00005700334,0.0001478923,0.0001679935,0.0001347565,0.00006320216,0.0003385033,0.000002371311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008604735,"about_ca_system_score_gemma":0.00009799674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001484401,"about_ca_topic_score_gemma":0.0002576549,"domain_scores_codex":[0.9976318,0.0004361753,0.0009153596,0.0005290385,0.0001525774,0.0003350531],"domain_scores_gemma":[0.9990533,0.0001698609,0.0004651214,0.000197307,0.00005711127,0.00005729258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004510511,0.004025992,0.007171261,0.0002586308,0.0008196025,0.00001217504,0.01017181,0.00001576075,0.9640881,0.0000236429,0.002139153,0.006763393],"study_design_scores_gemma":[0.01766739,0.003909929,0.0433435,0.0001758681,0.0003866422,0.00006651926,0.005127229,0.0002090683,0.9168066,0.00006719563,0.01133461,0.0009053978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949386,0.002925438,0.0003791566,0.0002843287,0.0001686506,0.001069925,0.00005783808,0.00002016254,0.0001558736],"genre_scores_gemma":[0.9974439,0.0001853962,0.001458655,0.00009591951,0.000006967472,0.00002728693,0.0004620568,0.00001517159,0.0003046192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04728141,"threshold_uncertainty_score":0.9999395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506334516909279,"score_gpt":0.2746510225225968,"score_spread":0.259587677353504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}