{"id":"W2971404000","doi":"10.33380//2305-2066-2019-8-3-91-100","title":"A Comparative Parallel Study of Pharmacokinetics and Immunogenicity Following Single Intravenous Administration of Bevacizumab Biosimilar RPH-001 (Manufactured by R-Pharm Group, Russia) and Avastin® (Manufactured by F. Hoffmann-La Roche Ltd., Switzerland) in Healthy Male Volunteers","year":2019,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Bevacizumab; Medicine; Pharmacokinetics; Immunogenicity; Biosimilar; Pharmacology; Antibody; Internal medicine; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347555,0.0006724509,0.0007504431,0.0002601252,0.000246897,0.0003590712,0.0002503808,0.0005629199,0.001746123],"category_scores_gemma":[0.001512359,0.0003709172,0.0005536925,0.0001842518,0.0006338551,0.0003765559,0.0002374656,0.0007141604,0.000556828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225604,"about_ca_system_score_gemma":0.0003458368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002168751,"about_ca_topic_score_gemma":0.0001421068,"domain_scores_codex":[0.9993461,0.0002026084,0.00003789184,0.0002183097,0.0001317671,0.00006333791],"domain_scores_gemma":[0.9989617,0.0002174185,0.0002054327,0.000210428,0.0001654651,0.0002396437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4444961,0.08323894,0.02596738,0.0006351028,0.0006756441,0.0004422666,0.001123084,0.001077812,0.3712495,0.0003600553,0.0008447565,0.06988939],"study_design_scores_gemma":[0.01572825,0.8476996,0.0862456,0.00001483196,0.0005696688,0.0008070385,0.0001218004,0.001669713,0.0443714,0.0002311172,0.002490837,0.00005014164],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981602,0.0002427159,0.0007291213,0.00001403866,0.00003820739,0.000353379,0.000123308,0.00001457462,0.0003244449],"genre_scores_gemma":[0.9960211,0.00024215,0.001294269,0.00008504774,0.0001011115,0.0006150238,0.0004957236,0.00001357075,0.001131866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001746123,"threshold_uncertainty_score":0.007126629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506334516909279,"score_gpt":0.2746510225225968,"score_spread":0.259587677353504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}