{"id":"W2971451438","doi":"10.1016/j.cmet.2019.08.005","title":"Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy","year":2019,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Institutes of Health; University of Texas Southwestern Medical Center; Canadian Institutes of Health Research; Welch Foundation","keywords":"Weight loss; Leptin; Sensitization; Insulin; Medicine; Reduction (mathematics); Endocrinology; Internal medicine; Diabetes mellitus; Obesity; Immunology; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002375682,0.0005955222,0.0007511005,0.0004073245,0.0003223397,0.0005190179,0.0005417017,0.0007198965,0.002990768],"category_scores_gemma":[0.0001963509,0.0002537112,0.000542941,0.0002614165,0.0007086138,0.0005652665,0.0005262756,0.002033061,0.0003699834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995275,"about_ca_system_score_gemma":0.000547098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000466739,"about_ca_topic_score_gemma":0.001102237,"domain_scores_codex":[0.9998007,0.00002562096,0.0000172215,0.00005356923,0.00004178255,0.00006112002],"domain_scores_gemma":[0.9998888,0.00001615261,0.00001849114,0.00001887054,0.00001048257,0.00004724842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01002873,0.001375211,0.0002431702,0.0001910761,0.00008932824,0.0001230328,0.0000447059,0.0003532803,0.9693273,0.0008794061,0.0002670388,0.01707772],"study_design_scores_gemma":[0.001733438,0.01480248,0.005175284,0.00005246865,0.0002324594,0.0004683288,0.000135577,0.002361148,0.9669626,0.00107421,0.006960699,0.00004122886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990639,0.001498888,0.004757613,0.0005664828,0.000240434,0.0001629628,0.0002462817,0.0001709918,0.001717446],"genre_scores_gemma":[0.9879615,0.001353747,0.005686949,0.000506519,0.00007911662,0.0002799657,0.0001953788,0.00007643494,0.003860354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002990768,"threshold_uncertainty_score":0.01000518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319144926524907,"score_gpt":0.2399090344219824,"score_spread":0.2267175851567333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}