{"id":"W2971451438","doi":"10.1016/j.cmet.2019.08.005","title":"Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy","year":2019,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Institutes of Health; University of Texas Southwestern Medical Center; Canadian Institutes of Health Research; Welch Foundation","keywords":"Weight loss; Leptin; Sensitization; Insulin; Medicine; Reduction (mathematics); Endocrinology; Internal medicine; Diabetes mellitus; Obesity; Immunology; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125272,0.0001144931,0.0001384528,0.0000670228,0.0001068232,0.00008158368,0.00007652795,0.00008367316,0.0003210849],"category_scores_gemma":[0.00002634691,0.0001086025,0.00002786882,0.000165408,0.00006840465,0.0004810622,0.00002919087,0.00009670736,0.0005113867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007255981,"about_ca_system_score_gemma":0.00002920523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002428696,"about_ca_topic_score_gemma":0.000001010497,"domain_scores_codex":[0.9989455,0.0001467657,0.0001639536,0.0003853407,0.0001894423,0.0001690358],"domain_scores_gemma":[0.9995229,0.00002527972,0.00008957271,0.0002255754,0.00003715967,0.00009952681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004194899,0.00006015614,0.0003561652,0.00001184274,0.000001063889,0.000003715397,0.0002305399,0.0003696925,0.982698,0.01305079,0.00005296626,0.003123133],"study_design_scores_gemma":[0.0005519644,0.00004792462,0.01754541,0.000004494718,0.0000123197,0.00002754115,0.00003683318,0.002136321,0.9570854,0.002726814,0.01966985,0.0001551338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928511,0.0001034084,0.00007742673,0.0002326488,0.0005558721,0.0001868652,0.0000032856,0.00005242059,0.005936991],"genre_scores_gemma":[0.9959094,0.0002908274,0.0001281251,0.0001349496,0.0003901426,0.000002234603,0.000009885754,0.00001441559,0.003120011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0256126,"threshold_uncertainty_score":0.6573012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319144926524907,"score_gpt":0.2399090344219824,"score_spread":0.2267175851567333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}