{"id":"W2971454236","doi":"10.1039/c9sc04074a","title":"Valency engineering of monomeric enzymes for self-assembling biocatalytic hydrogels","year":2019,"lang":"en","type":"article","venue":"Chemical Science","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Interface Biologics (Canada)","funders":"Deutsche Forschungsgemeinschaft","keywords":"Self-healing hydrogels; Valency; Monomer; Enzyme; Chemistry; Protein engineering; Materials science; Organic chemistry; Polymer chemistry; Polymer science; Chemical engineering; Nanotechnology; Polymer; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809817,0.00007465996,0.0001022186,0.00004202241,0.00002203182,0.00001253883,0.0002562616,0.00004843994,0.00000500551],"category_scores_gemma":[0.000136339,0.00006824726,0.00006163224,0.0002945849,0.00005460902,0.00001069306,0.0000776784,0.00002394397,0.000004511227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000173782,"about_ca_system_score_gemma":0.00006030412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000011524,"about_ca_topic_score_gemma":4.950822e-8,"domain_scores_codex":[0.9992763,0.000002031981,0.0001459889,0.0002881831,0.0001073176,0.0001802035],"domain_scores_gemma":[0.999558,0.00001468799,0.00005649423,0.0002334496,0.00008315031,0.00005422926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003363699,0.0000229892,0.000612782,0.00003991486,0.00000565077,1.916893e-8,0.00001453567,0.0001631122,0.9987476,0.000130079,0.00001942942,0.0002404751],"study_design_scores_gemma":[0.0001337006,0.00005121263,0.0001326161,0.00001104389,0.000008107865,0.000001195605,0.00001109893,0.005152695,0.9934736,0.00001013748,0.0009225958,0.00009195357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963439,0.0004004441,0.002865713,0.00001029471,0.00006934953,0.0001388401,0.000002999015,0.00001039016,0.0001581287],"genre_scores_gemma":[0.9976053,0.00002498657,0.00221886,0.00001714128,0.00004095906,0.00001248114,0.00002611813,0.000007602249,0.00004653176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005274007,"threshold_uncertainty_score":0.2783042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005443772889117304,"score_gpt":0.2287050957285008,"score_spread":0.2232613228393835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}