{"id":"W2971629652","doi":"10.1080/14756366.2019.1651723","title":"Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities","year":2019,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Science and Technology Development Fund","keywords":"Pyridazine; Chemistry; Potency; Umbilical vein; Stereochemistry; VEGF receptors; Kinase insert domain receptor; IC50; Scaffold; Human umbilical vein endothelial cell; In vitro; Combinatorial chemistry; Pharmacology; Biochemistry; Vascular endothelial growth factor; Vascular endothelial growth factor A; Cancer research; Biology; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003140232,0.0001415307,0.0003931429,0.00007359069,0.00001687274,0.000005782248,0.00005717165,0.00009792506,0.00001464806],"category_scores_gemma":[0.00005143366,0.00009458083,0.000166321,0.00007119237,0.0002034145,0.00005293074,0.00002319851,0.00007938795,1.728516e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003949243,"about_ca_system_score_gemma":0.000243924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002991531,"about_ca_topic_score_gemma":0.000001354079,"domain_scores_codex":[0.9991431,0.00003354821,0.000395281,0.0001235324,0.0002190041,0.00008559543],"domain_scores_gemma":[0.9984148,0.00009036878,0.001037419,0.0001284209,0.0002761377,0.00005283142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00346334,0.0002899727,0.002301923,0.0004523592,0.0002597912,5.791193e-7,0.00008099078,0.0001847385,0.9920149,0.000001970683,0.00003755536,0.0009119092],"study_design_scores_gemma":[0.001311514,0.001340396,0.01359372,0.0008973149,0.0001074422,0.00005458608,0.0006930763,0.0001916469,0.9817165,0.000003730463,0.00000556941,0.00008456601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958809,0.0004521259,0.003224408,0.00004201184,0.00002770758,0.00009344157,0.0001001083,9.389368e-7,0.0001783767],"genre_scores_gemma":[0.9995013,0.0002443988,0.0001585733,0.0000146727,0.00005279392,0.00000184093,0.00001127347,0.000008322228,0.000006818202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0112918,"threshold_uncertainty_score":0.3856894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667178401778107,"score_gpt":0.2740690605330864,"score_spread":0.2573972765153053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}