{"id":"W2971629652","doi":"10.1080/14756366.2019.1651723","title":"Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities","year":2019,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Science and Technology Development Fund","keywords":"Pyridazine; Chemistry; Potency; Umbilical vein; Stereochemistry; VEGF receptors; Kinase insert domain receptor; IC50; Scaffold; Human umbilical vein endothelial cell; In vitro; Combinatorial chemistry; Pharmacology; Biochemistry; Vascular endothelial growth factor; Vascular endothelial growth factor A; Cancer research; Biology; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150212,0.0002628223,0.0002659832,0.0001582629,0.0001016368,0.0001652817,0.0002608939,0.0002173746,0.0008004713],"category_scores_gemma":[0.0001011933,0.0001211077,0.0001244598,0.0001645936,0.0001241123,0.0002549605,0.0001383048,0.0003464372,0.0001967968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001950222,"about_ca_system_score_gemma":0.0002154501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002323337,"about_ca_topic_score_gemma":0.000584692,"domain_scores_codex":[0.9999638,0.000005060023,0.000002721116,0.00000936709,0.000008724844,0.00001041963],"domain_scores_gemma":[0.9999698,0.000005307151,0.000009772447,0.000002382694,0.000004838432,0.000007761565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002169003,0.0001782553,0.0001939118,0.0003151688,0.00001346516,0.0003815313,0.00005178622,0.003269644,0.9761719,0.001398305,0.0002087381,0.01760045],"study_design_scores_gemma":[0.0001959794,0.00228918,0.001803563,0.00002831354,0.00005010825,0.000984933,0.00003264767,0.00606539,0.9769781,0.000411389,0.01112977,0.00003062089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665423,0.006081104,0.02297156,0.00031028,0.00004146015,0.0002206688,0.0004601887,0.0001100898,0.00326235],"genre_scores_gemma":[0.9815789,0.003047067,0.01290665,0.00008160141,0.00001089409,0.00006380946,0.000328796,0.000007029542,0.001975188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008004713,"threshold_uncertainty_score":0.002677798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667178401778107,"score_gpt":0.2740690605330864,"score_spread":0.2573972765153053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}