{"id":"W2971636403","doi":"10.1126/sciadv.aax3013","title":"Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Health and Medical Research Council","keywords":"Exotoxin; Streptococcus pyogenes; Superantigen; Antibody; Toxic shock syndrome; Immunology; Biology; Vaccination; Streptococcus; Microbiology; Virology; Immune system; Staphylococcus aureus; Toxin; Genetics; T cell; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002468109,0.0001184986,0.000225438,0.0001032703,0.0002249821,0.00003410525,0.0001874372,0.00002640613,0.00002593083],"category_scores_gemma":[0.0001386538,0.00005949802,0.0000405648,0.0008242737,0.0006475294,0.0002746116,0.000100452,0.000104342,0.0000129462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004584969,"about_ca_system_score_gemma":0.0001499119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001812634,"about_ca_topic_score_gemma":0.0004382277,"domain_scores_codex":[0.9989362,0.0000528921,0.0002038528,0.0003372397,0.0002448878,0.0002249598],"domain_scores_gemma":[0.9993738,0.00006670913,0.00006249727,0.000310438,0.0001278129,0.0000587457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000146507,0.0001625836,0.7871149,0.00005497261,0.00002128776,0.00001889369,0.001091702,0.00004248975,0.2088312,0.0004486312,0.00001835963,0.002048429],"study_design_scores_gemma":[0.001768241,0.0008795116,0.9098691,0.0006296801,0.00002226346,0.0001375895,0.00159204,0.0001233333,0.08343361,0.0001337015,0.001268843,0.0001420546],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955821,0.0004256923,0.00001386354,0.001073158,0.0001161341,0.002337712,0.000006103503,0.00001328079,0.000431978],"genre_scores_gemma":[0.9985588,0.00002460298,0.0002970151,0.0001464825,0.000008134401,0.000103891,7.313026e-7,0.000005359898,0.0008550476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1253976,"threshold_uncertainty_score":0.2426259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831981131739895,"score_gpt":0.2916320648022045,"score_spread":0.2733122534848055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}