{"id":"W2971686951","doi":"10.1056/nejmoa1902678","title":"Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agios Pharmaceuticals","keywords":"Medicine; Pyruvate kinase deficiency; Pyruvate kinase; Internal medicine; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000769334,0.0003336288,0.0008484862,0.0001569427,0.0001681805,0.000347605,0.0002699222,0.0003320311,0.001626394],"category_scores_gemma":[0.0008895764,0.0001358444,0.0004090795,0.0001866469,0.0002953561,0.0002564247,0.0001237629,0.001063899,0.0002469391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105409,"about_ca_system_score_gemma":0.0003498322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002007479,"about_ca_topic_score_gemma":0.000349391,"domain_scores_codex":[0.9997688,0.0001141478,0.00002257197,0.00003774892,0.00003156213,0.00002518342],"domain_scores_gemma":[0.9995023,0.0001580809,0.0001819908,0.00003810049,0.00002797499,0.00009157351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5190468,0.01345537,0.03158265,0.001317397,0.001409824,0.0009444754,0.0002204295,0.002071951,0.09172978,0.0002211371,0.002909655,0.3350905],"study_design_scores_gemma":[0.2139972,0.6342584,0.1078521,0.0001878837,0.001468758,0.004064918,0.0001065139,0.002677011,0.02935681,0.0002661512,0.005728721,0.0000355862],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949145,0.003703554,0.0002443663,0.0001200112,0.00002748796,0.0001485002,0.000238027,0.00002803898,0.0005755204],"genre_scores_gemma":[0.9983672,0.0007268635,0.000213493,0.0001106388,0.00003760767,0.00008527059,0.0002347565,0.000003975108,0.0002201538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626394,"threshold_uncertainty_score":0.005440831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437216365348478,"score_gpt":0.264274395417618,"score_spread":0.2499022317641333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}