{"id":"W2971693570","doi":"10.1101/gad.328773.119","title":"Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; American Cancer Society; Making Headway Foundation; Crohn's and Colitis Foundation; York University; Howard Hughes Medical Institute","keywords":"PRC2; EZH2; Histone H3; Biology; Chromatin; Histone; Histone methylation; Cell biology; Methyltransferase; Histone methyltransferase; Methylation; Genetics; DNA methylation; DNA; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000444047,0.0001423822,0.000165611,0.0001925429,0.000030741,0.00001323374,0.00007909654,0.0001475679,0.00002412993],"category_scores_gemma":[0.00003598279,0.0001420058,0.00003365175,0.000253181,0.00001685411,0.000007610387,0.00008745044,0.00004166535,0.000008347824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002331097,"about_ca_system_score_gemma":0.0001363597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001985025,"about_ca_topic_score_gemma":0.00002482626,"domain_scores_codex":[0.9988651,0.00005837805,0.0003837504,0.000334631,0.0001803402,0.000177805],"domain_scores_gemma":[0.999489,0.00001840002,0.0001534039,0.0001912229,0.0001004604,0.00004751288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002465297,0.00003708409,0.1838914,0.00005035129,0.0000163294,3.447235e-7,0.000449746,0.00006507382,0.7797977,0.00001041866,0.000006033652,0.03565084],"study_design_scores_gemma":[0.0003736701,0.0001003118,0.2647326,0.000007303024,0.00000620078,6.710622e-7,0.00002837986,0.0001625778,0.7330148,0.0001844776,0.00125168,0.0001372783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929492,0.005535352,0.0008606086,0.00004807671,0.00009007222,0.0003848113,0.000003789387,0.00000874218,0.0001193839],"genre_scores_gemma":[0.9939675,0.0007554751,0.005026024,0.00001295896,0.00004899197,0.00002233926,0.0000680788,0.00001682911,0.00008178598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0808412,"threshold_uncertainty_score":0.5790829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009501483699544563,"score_gpt":0.2470397461614308,"score_spread":0.2375382624618863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}