{"id":"W2971693570","doi":"10.1101/gad.328773.119","title":"Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; American Cancer Society; Making Headway Foundation; Crohn's and Colitis Foundation; York University; Howard Hughes Medical Institute","keywords":"PRC2; EZH2; Histone H3; Biology; Chromatin; Histone; Histone methylation; Cell biology; Methyltransferase; Histone methyltransferase; Methylation; Genetics; DNA methylation; DNA; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113893,0.000311808,0.0003104042,0.0003432526,0.0001448118,0.0002549053,0.0001957408,0.0001629696,0.001454599],"category_scores_gemma":[0.0001322996,0.0001703468,0.0002250607,0.0002629253,0.000285989,0.0001329887,0.0003098779,0.0003897523,0.0003790563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111158,"about_ca_system_score_gemma":0.0003319409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159844,"about_ca_topic_score_gemma":0.001299353,"domain_scores_codex":[0.9998558,0.00001558092,0.00001469483,0.00002609712,0.00005145888,0.00003636596],"domain_scores_gemma":[0.9998307,0.00001606969,0.00006176442,0.00002005455,0.000008847036,0.00006254215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001933541,0.00002836472,0.002343853,0.00002914793,0.00001560487,0.0004734559,0.00002333303,0.0001929314,0.9945021,0.00018817,0.00005181706,0.001957924],"study_design_scores_gemma":[0.00003868696,0.0004135146,0.06470168,0.000004495041,0.00003543745,0.004296748,0.00009270124,0.001460409,0.9261838,0.0001674549,0.002597328,0.000007662476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998237,0.0002805178,0.0007878316,0.00002373912,0.000004073464,0.000006283884,0.0001792616,0.00006864178,0.000412646],"genre_scores_gemma":[0.9985121,0.0001848518,0.0003067683,0.000008934633,0.00000206597,0.000007893461,0.0002673749,0.00001347908,0.0006965676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454599,"threshold_uncertainty_score":0.004866123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009501483699544563,"score_gpt":0.2470397461614308,"score_spread":0.2375382624618863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}