{"id":"W2971696868","doi":"10.1002/cbic.201900449","title":"The Biosynthetic Gene Cluster of Pyrazomycin—A C‐Nucleoside Antibiotic with a Rare Pyrazole Moiety","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; Natural Science Foundation of Zhejiang Province; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Pyrazole; Stereochemistry; Biosynthesis; Gene cluster; Moiety; Chemistry; Nucleoside; Enzyme; Biochemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005624747,0.0002593802,0.0002607778,0.0002640981,0.000181262,0.0002315126,0.0001391407,0.0002074961,0.0007591763],"category_scores_gemma":[0.00009587825,0.00009893512,0.0002160747,0.0002540089,0.0001543104,0.0001178637,0.000228379,0.0003583975,0.0005243332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000456988,"about_ca_system_score_gemma":0.0003898827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001324664,"about_ca_topic_score_gemma":0.000738532,"domain_scores_codex":[0.9999014,0.000009088081,0.000005414283,0.00003937426,0.00002678669,0.00001787751],"domain_scores_gemma":[0.9998928,0.00001636888,0.00002510298,0.00001273808,0.00001436693,0.00003848134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003419551,0.000005341772,0.000185663,0.00001489046,8.686471e-7,0.00004539259,0.000008327565,0.00004720046,0.9987292,0.00007854236,0.00001571532,0.0008347861],"study_design_scores_gemma":[0.00001328669,0.0001320767,0.01968635,0.000008740539,0.00001185161,0.0009005833,0.00007216381,0.001698579,0.9715706,0.0001997531,0.005695149,0.00001092711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870554,0.0006476119,0.008586057,0.0001529109,0.00003095286,0.00005599341,0.001817407,0.0002143403,0.001439304],"genre_scores_gemma":[0.9816213,0.0003286995,0.009525511,0.00003723938,0.00001335553,0.00004151169,0.004342274,0.00003869669,0.004051353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324664,"threshold_uncertainty_score":0.003315687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003812620731431928,"score_gpt":0.2103051443360723,"score_spread":0.2064925236046403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}