{"id":"W2971696868","doi":"10.1002/cbic.201900449","title":"The Biosynthetic Gene Cluster of Pyrazomycin—A C‐Nucleoside Antibiotic with a Rare Pyrazole Moiety","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; Natural Science Foundation of Zhejiang Province; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Pyrazole; Stereochemistry; Biosynthesis; Gene cluster; Moiety; Chemistry; Nucleoside; Enzyme; Biochemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232514,0.0002458143,0.0002303218,0.00002991684,0.00009744569,0.00003745625,0.0005166504,0.0002235333,0.00002882093],"category_scores_gemma":[0.0001031706,0.00016033,0.0001691542,0.0001884737,0.0003573861,0.000003122037,0.0003294335,0.0001851097,0.00005798143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001653134,"about_ca_system_score_gemma":0.0001108566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001438579,"about_ca_topic_score_gemma":0.000005944834,"domain_scores_codex":[0.9984044,0.00003468376,0.0002559941,0.000512283,0.0003168324,0.0004758408],"domain_scores_gemma":[0.9985626,0.00002642587,0.0001115725,0.0009321171,0.0002279797,0.0001393096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002844329,0.0000827806,0.001108667,0.00008345982,0.0001046601,0.000002142764,0.0000186904,0.000007945715,0.9956714,0.00007380613,0.0016893,0.0008727283],"study_design_scores_gemma":[0.0009068683,0.0002966977,0.0005356938,0.00004772629,0.00002334947,0.00002485743,0.00006923112,0.00005367759,0.9789044,0.00002126032,0.01887378,0.0002425113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930356,0.001241961,0.00006371651,0.0004374562,0.00008478448,0.0004229313,0.00001648673,0.00001686971,0.004680168],"genre_scores_gemma":[0.9967915,0.0002191469,0.000334541,0.0002531867,0.0001101447,0.00001235085,0.00007709802,0.00005085017,0.00215116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01718448,"threshold_uncertainty_score":0.6538068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003812620731431928,"score_gpt":0.2103051443360723,"score_spread":0.2064925236046403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}