{"id":"W2971703295","doi":"10.1371/journal.pgen.1008376","title":"Pleiotropic role of Drosophila phosphoribosyl pyrophosphate synthetase in autophagy and lysosome homeostasis","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":true,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; Lysosome; Autophagy; Neurodegeneration; Cell biology; Mutation; Mutant; Genetics; Phenotype; Missense mutation; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":{"nature":"Retraction","reason":"Error in Data;Error in Results and/or Conclusions;","date":"2/4/2022 0:00","openalex_flagged":true},"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007456611,0.0003576187,0.0001482679,0.0003515406,0.0001251768,0.0001826569,0.0001185691,0.0001710136,0.0009813841],"category_scores_gemma":[0.00005126435,0.0001066325,0.0001369641,0.0001194165,0.0002156363,0.0001080809,0.0002743835,0.0002131492,0.0001668113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039673,"about_ca_system_score_gemma":0.0001592772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003662347,"about_ca_topic_score_gemma":0.0008140455,"domain_scores_codex":[0.9999273,0.00001530431,0.000008384872,0.00002057214,0.00001699875,0.00001149032],"domain_scores_gemma":[0.9999429,0.000006731822,0.00001864977,0.000006640874,0.000004594479,0.0000205294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169982,0.000005127579,0.0007677756,0.00001948437,0.00000489727,0.0002355509,0.000006201324,0.00006053412,0.997239,0.0001790648,0.00002682251,0.001338645],"study_design_scores_gemma":[0.00004491271,0.0002717614,0.07504714,0.00001693746,0.00005393125,0.003881136,0.0000698728,0.002102328,0.9145434,0.0004369958,0.003514129,0.00001738472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948014,0.001552975,0.001448656,0.00006978405,0.000007540437,0.000007583998,0.0003826032,0.00006860257,0.001660794],"genre_scores_gemma":[0.997347,0.0004355471,0.001106353,0.00002101506,0.000002686278,0.000006228937,0.0001717541,0.00001044613,0.0008989674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009813841,"threshold_uncertainty_score":0.003283083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005494249115965363,"score_gpt":0.2181296741736387,"score_spread":0.2126354250576734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}