{"id":"W2971713811","doi":"10.1161/hyp.74.suppl_1.p3003","title":"Abstract P3003: miR-338-3p Down-Regulation Caused Up-Regulation of Alkaline Ceramidase 2 and Glutathione Peroxidase 3 mRNAs in Subcutaneous Small Arteries of Hypertensive Patients With Chronic Kidney Disease","year":2019,"lang":"en","type":"article","venue":"Hypertension","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Jewish General Hospital","funders":"","keywords":"Kidney disease; Endothelial dysfunction; Internal medicine; Endocrinology; Renal function; Fold change; Blood pressure; microRNA; Medicine; Messenger RNA; RNA; Kidney; Gene expression; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085997,0.0002169535,0.000312846,0.0002877339,0.0001502838,0.0001738091,0.000100512,0.0001475288,0.002738662],"category_scores_gemma":[0.0001568595,0.0001057151,0.000243678,0.0001927065,0.0001740549,0.0000712209,0.0001353801,0.0004138738,0.0003947039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344899,"about_ca_system_score_gemma":0.0001169176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006682487,"about_ca_topic_score_gemma":0.000697331,"domain_scores_codex":[0.9998921,0.00001096696,0.000007241908,0.00003972337,0.00002616182,0.00002375069],"domain_scores_gemma":[0.9999031,0.00001972703,0.00002633714,0.000006724336,0.00001603747,0.00002804619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002243164,0.00007247953,0.005394405,0.00006465981,0.00002138659,0.0002117079,0.00005234464,0.00002395312,0.989491,0.00002253566,0.0001357359,0.002266642],"study_design_scores_gemma":[0.0002078685,0.001690683,0.5215119,0.00001939714,0.000175469,0.001600156,0.000265275,0.001747203,0.470189,0.0001452639,0.002424064,0.00002380411],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997139,0.0004174329,0.0008507457,0.00005679445,0.00002724186,0.00001961605,0.0009590382,0.00003873651,0.0004915452],"genre_scores_gemma":[0.9964319,0.0001959382,0.001191781,0.00006214364,0.00001940012,0.00006018897,0.0006882392,0.0000126821,0.00133777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002738662,"threshold_uncertainty_score":0.009161711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007581632074348127,"score_gpt":0.2068505332458359,"score_spread":0.1992689011714877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}