{"id":"W2971760086","doi":"10.1007/s00384-019-03389-w","title":"Impact of age on toxicity and efficacy of 5-FU-based combination chemotherapy among patients with metastatic colorectal cancer; a pooled analysis of five randomized trials","year":2019,"lang":"en","type":"article","venue":"International Journal of Colorectal Disease","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Colorectal cancer; Odds ratio; Proportional hazards model; Adverse effect; Diarrhea; Logistic regression; Gastroenterology; Surgery; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01303586,0.001882054,0.007961004,0.001213949,0.0003499181,0.001981627,0.0007922711,0.001776961,0.001352161],"category_scores_gemma":[0.016071,0.0008884206,0.01895881,0.00146564,0.000884493,0.001358703,0.0008492953,0.001897615,0.0001176102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001012462,"about_ca_system_score_gemma":0.0008116014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606229,"about_ca_topic_score_gemma":0.003059015,"domain_scores_codex":[0.9890161,0.007378684,0.001664668,0.0009739354,0.0006432499,0.0003233624],"domain_scores_gemma":[0.9894634,0.006757548,0.00246424,0.0006077004,0.0003799097,0.0003270229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4627878,0.0002505731,0.01687326,0.01233517,0.4864986,0.00009910193,0.00007841895,0.001866603,0.001052632,0.0001142292,0.0003474343,0.01769621],"study_design_scores_gemma":[0.1231249,0.02168578,0.04183071,0.001071572,0.8080252,0.0001615957,0.00009474766,0.001316039,0.0006388738,0.000468967,0.001494723,0.00008691476],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5597563,0.4327716,0.002479191,0.000372348,0.0007258225,0.0009314317,0.001178824,0.00008388187,0.001700631],"genre_scores_gemma":[0.9735042,0.02369262,0.0009174165,0.0003534985,0.0002824847,0.0003246608,0.000546246,0.000019684,0.0003591584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01303586,"threshold_uncertainty_score":0.06894106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274560258977976,"score_gpt":0.3326382503969765,"score_spread":0.3198926478071968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}