{"id":"W2971777950","doi":"10.1016/j.jpsychires.2019.09.002","title":"Towards precision medicine in generalized anxiety disorder: Review of genetics and pharmaco(epi)genetics","year":2019,"lang":"en","type":"review","venue":"Journal of Psychiatric Research","topic":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","field":"Psychology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; St. Joseph’s Healthcare Hamilton; McMaster University; University of Toronto; Sunnybrook Health Science Centre; Centre for Addiction and Mental Health","funders":"Ontario Ministry of Research, Innovation and Science; Centre for Addiction and Mental Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Generalized anxiety disorder; Pharmacogenetics; Precision medicine; Anxiety; Neuroimaging; Drug response; Disease; Epigenetics; Medicine; Psychiatry; Clinical psychology; Psychology; Biology; Genetics; Drug; Genotype; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004052049,0.001134338,0.004251302,0.003634949,0.0003214044,0.001703193,0.001547697,0.002448964,0.003480105],"category_scores_gemma":[0.005425466,0.0004855928,0.001766268,0.003096732,0.001096496,0.002099498,0.00137281,0.003195761,0.0007805236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001274437,"about_ca_system_score_gemma":0.002671876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00251686,"about_ca_topic_score_gemma":0.005994369,"domain_scores_codex":[0.999167,0.000266239,0.0001459855,0.0001491813,0.0002213417,0.00005030617],"domain_scores_gemma":[0.9938539,0.004898304,0.0003556509,0.0001054143,0.000619965,0.0001667191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001686769,0.0001001357,0.0003506182,0.05002828,0.00072541,0.0001796835,0.00006607576,0.0004634359,0.0005511061,0.004597096,0.02309977,0.9196698],"study_design_scores_gemma":[0.0003116619,0.0003671813,0.003803887,0.05297224,0.002946441,0.00153687,0.0001973081,0.0004753323,0.0003717983,0.01291905,0.9239784,0.000119784],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002135456,0.9994799,0.00007421456,0.0002623025,0.00007519701,0.000001857886,0.000007102593,0.000002481914,0.00007557403],"genre_scores_gemma":[0.0002807706,0.9987106,0.0002633948,0.0004794944,0.0001974697,0.000004258899,0.00001244397,0.000001006764,0.00005054942],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004251302,"threshold_uncertainty_score":0.02142948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2028139046325804,"score_gpt":0.5465019033494948,"score_spread":0.3436879987169144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}