{"id":"W2971780227","doi":"10.3389/fimmu.2019.02214","title":"Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Sanofi Pasteur; Innovative Medicines Initiative; University of British Columbia; Landspítali Háskólasjúkrahús; Háskóli Íslands; Sanofi; Icelandic Centre for Research; European Commission","keywords":"Germinal center; Immune system; Spleen; Immunology; Medicine; Bone marrow; Adjuvant; Vaccination; Antibody; Immunization; Conjugate vaccine; Biology; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137752,0.00052118,0.0002843837,0.0003510977,0.00007258175,0.0001782156,0.0001733237,0.0002678572,0.0007834907],"category_scores_gemma":[0.000203393,0.0001330082,0.0001761865,0.00009577892,0.0001517457,0.0001955533,0.0001961984,0.0006015526,0.0002583547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599526,"about_ca_system_score_gemma":0.0002898232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004647878,"about_ca_topic_score_gemma":0.0006536333,"domain_scores_codex":[0.999838,0.00002818908,0.00001822988,0.00003143901,0.00004079649,0.00004329746],"domain_scores_gemma":[0.9997719,0.00002926114,0.00007430969,0.00001718077,0.00002669827,0.00008077009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002742377,0.00006339524,0.0002212549,0.00004883197,0.000003007898,0.00003858115,0.00001942606,0.00006975406,0.9974273,0.0000424845,0.0000201907,0.001771604],"study_design_scores_gemma":[0.00004243515,0.002251608,0.008502387,0.00002124611,0.00002527494,0.0002530032,0.00002917911,0.0005640444,0.9866856,0.00004743279,0.001572211,0.000005554344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958521,0.00186269,0.001057144,0.0000500998,0.0000196713,0.00003006239,0.0002327564,0.00005965025,0.0008357404],"genre_scores_gemma":[0.9941133,0.001363469,0.001727284,0.00008866904,0.0000189838,0.00004983145,0.0004089902,0.00001894246,0.002210583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007834907,"threshold_uncertainty_score":0.002621055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005535589826962193,"score_gpt":0.2138931586911009,"score_spread":0.2083575688641387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}