{"id":"W2971815111","doi":"10.1080/19336896.2019.1651180","title":"Deciphering the BSE-type specific cell and tissue tropisms of atypical (H and L) and classical BSE","year":2019,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Medical University of South Carolina","keywords":"Bovine spongiform encephalopathy; Tropism; Biology; Tissue tropism; Virology; Nervous system; Scrapie; Prion protein; Infectivity; Pathology; Disease; Medicine; Virus; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003369326,0.000178465,0.0002534433,0.0007922951,0.0001485426,0.000468437,0.0001245254,0.0003327441,0.0005891689],"category_scores_gemma":[0.0003828596,0.000209284,0.0001083927,0.0002582146,0.000436507,0.0003962549,0.0002405314,0.00018823,0.000251851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013365,"about_ca_system_score_gemma":0.00007050958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009527825,"about_ca_topic_score_gemma":0.001276601,"domain_scores_codex":[0.9997813,0.00004392332,0.00002172005,0.00004913524,0.00003864121,0.00006532682],"domain_scores_gemma":[0.9997048,0.00007467439,0.00007517592,0.00002387782,0.00006558661,0.00005585732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004533738,0.00003369738,0.04109569,0.00008256586,0.00002248273,0.0006171808,0.0004319327,0.00007011311,0.9546931,0.0001113419,0.00002254101,0.002365846],"study_design_scores_gemma":[0.00001471716,0.0006805803,0.9014188,0.0000213449,0.00004596244,0.005095688,0.001729509,0.001047067,0.08773281,0.0002824292,0.001911009,0.00002000975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981897,0.0006192821,0.0005051822,0.000008779608,0.000002891441,0.00001011404,0.00008914385,0.000005864134,0.0005690263],"genre_scores_gemma":[0.9986784,0.0004208411,0.0004656812,0.00002018891,0.000008692125,0.000007559811,0.0001285459,0.000002974785,0.0002671424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009527825,"threshold_uncertainty_score":0.001970947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006178342162805614,"score_gpt":0.2212033894598116,"score_spread":0.2150250472970059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}