{"id":"W2971821708","doi":"10.1016/j.molcel.2019.07.038","title":"Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation","year":2019,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":359,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council","keywords":"Enhancer; Biology; Enhancer RNAs; Cell biology; Promoter activity; Computational biology; Genetics; Transcription factor; Promoter; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429714,0.0001416255,0.0002535593,0.0002125817,0.0001665241,0.0003362941,0.0003109993,0.0003383521,0.003847126],"category_scores_gemma":[0.000375575,0.000218949,0.0001773405,0.0001773377,0.0003747313,0.0002852293,0.0005248274,0.0008180279,0.000733769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002759279,"about_ca_system_score_gemma":0.0001875914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003422174,"about_ca_topic_score_gemma":0.0004202902,"domain_scores_codex":[0.9997767,0.00002131137,0.00001182671,0.00008395134,0.00007563194,0.00003061097],"domain_scores_gemma":[0.9995182,0.0001841725,0.00009149229,0.00008441753,0.00004614033,0.00007559392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006521455,0.000007651526,0.0003446985,0.00002494186,0.000003040602,0.00005894032,0.00001965863,0.00008559302,0.9983782,0.0001989031,0.0000207246,0.0007923031],"study_design_scores_gemma":[0.00001039929,0.0001012674,0.01657412,0.000004423936,0.000008334735,0.000606271,0.0000352543,0.0007805895,0.978604,0.000312196,0.00295827,0.000005005319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731694,0.002381147,0.01809352,0.0001552518,0.00005272402,0.00003029563,0.000501479,0.0003443692,0.005271897],"genre_scores_gemma":[0.994823,0.0002968505,0.00229988,0.00005323582,0.000009915128,0.00002247595,0.0003416499,0.0000384224,0.002114452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003847126,"threshold_uncertainty_score":0.01286989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004273310709198124,"score_gpt":0.2080018998472716,"score_spread":0.2037285891380735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}