{"id":"W2971876915","doi":"10.1093/nar/gkz777","title":"G-quadruplex located in the 5′UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Biology; Upstream open reading frame; Five prime untranslated region; Internal ribosome entry site; Untranslated region; Translation (biology); Messenger RNA; Eukaryotic translation; Three prime untranslated region; Gene isoform; Start codon; Open reading frame; Molecular biology; Stop codon; RNA; Cell biology; Genetics; Gene; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282911,0.0002408095,0.0002293816,0.0001449999,0.0001370332,0.0001751719,0.0001473896,0.0001899745,0.001516713],"category_scores_gemma":[0.0001391887,0.0001196356,0.0001838838,0.00006564249,0.0002362216,0.0001328421,0.0001294157,0.0003615818,0.0003487886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245005,"about_ca_system_score_gemma":0.0001527953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001797812,"about_ca_topic_score_gemma":0.0003164637,"domain_scores_codex":[0.9998766,0.00003160463,0.00001049819,0.0000309473,0.00002801041,0.00002227102],"domain_scores_gemma":[0.999882,0.00002823989,0.00004488124,0.00001098716,0.000009630246,0.00002416794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009034252,0.0000151111,0.00008647485,0.00002352495,0.000003943768,0.00001991112,0.000004688869,0.00005532469,0.998818,0.00006121625,0.00001897773,0.0008025148],"study_design_scores_gemma":[0.00001321452,0.0005331091,0.002456758,0.00000384866,0.00001555892,0.0001456577,0.00000800121,0.0005657652,0.9950621,0.0000545563,0.001135965,0.000005580724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950601,0.001094199,0.002674184,0.00005980979,0.00004432935,0.0000213763,0.0001757339,0.000108698,0.000761374],"genre_scores_gemma":[0.9963962,0.0002876217,0.001949394,0.00006426434,0.00001160434,0.0000191924,0.0002830891,0.00001789195,0.0009706463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516713,"threshold_uncertainty_score":0.005073845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280745763450783,"score_gpt":0.295101105045712,"score_spread":0.2722936474112042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}