{"id":"W2971968715","doi":"10.1161/atvbaha.119.313247","title":"Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal; Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Proprotein convertase; PCSK9; Kexin; Subtilisin; LDL receptor; Chemistry; Phosphorylation; Sequence (biology); Similarity (geometry); Biochemistry; Lipoprotein; Enzyme; Computer science; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059719,0.0003605626,0.0001524351,0.0001371128,0.0001182361,0.0001322082,0.0001011547,0.0001873585,0.001752589],"category_scores_gemma":[0.0001086071,0.00009069284,0.0002530463,0.00008362568,0.0001823789,0.0001465883,0.0001459444,0.000236173,0.0003554715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002769449,"about_ca_system_score_gemma":0.0001469637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003097281,"about_ca_topic_score_gemma":0.0003499569,"domain_scores_codex":[0.99992,0.00001263896,0.000007377655,0.00001984663,0.00001504479,0.00002510641],"domain_scores_gemma":[0.9999193,0.000009984654,0.00003259151,0.000007586477,0.000006488055,0.00002418309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001612415,0.00001325945,0.0002327278,0.00001939154,0.000003453371,0.00004705558,0.000003874798,0.00003306886,0.9988876,0.00003419898,0.00001412628,0.0005499841],"study_design_scores_gemma":[0.00001525135,0.0002055758,0.005011952,0.000002706609,0.000009913648,0.0003285301,0.000007172268,0.0005020745,0.9931502,0.00001768798,0.0007468982,0.000002028158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978229,0.000448083,0.0008898837,0.00003711151,0.00001256467,0.000008969346,0.0001168026,0.00002826876,0.0006354098],"genre_scores_gemma":[0.9966894,0.0003476645,0.001317736,0.00003021649,0.000006731622,0.00001398738,0.0002372381,0.00001089459,0.001346102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752589,"threshold_uncertainty_score":0.005863011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988601374111497,"score_gpt":0.2741845428217571,"score_spread":0.2442985290806422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}