{"id":"W2971968715","doi":"10.1161/atvbaha.119.313247","title":"Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal; Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Proprotein convertase; PCSK9; Kexin; Subtilisin; LDL receptor; Chemistry; Phosphorylation; Sequence (biology); Similarity (geometry); Biochemistry; Lipoprotein; Enzyme; Computer science; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001693449,0.0004900366,0.001216087,0.00008074503,0.0002656389,0.00004823564,0.0002657085,0.0003705655,0.000241243],"category_scores_gemma":[0.0001071182,0.0003212509,0.0003846551,0.000396067,0.0004116233,0.0001832081,0.0001551701,0.0004038286,0.00005899357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001202075,"about_ca_system_score_gemma":0.0001761839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004182402,"about_ca_topic_score_gemma":0.0004953342,"domain_scores_codex":[0.99646,0.0005932802,0.0006750024,0.001082661,0.0005635727,0.000625447],"domain_scores_gemma":[0.9974967,0.00009196558,0.0002719455,0.001410739,0.0003901843,0.0003384543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001291056,0.0002797724,0.04831674,0.0004442351,0.0003914296,2.462495e-7,0.0004814364,0.000004732567,0.9462061,0.0000741766,0.0001794896,0.003492545],"study_design_scores_gemma":[0.00201273,0.001969481,0.7249881,0.0003845885,0.0002465678,0.000002423573,0.0003696894,0.0001360458,0.2664155,0.00002931503,0.002999119,0.0004463802],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933136,0.0007407818,0.0004176726,0.001621537,0.0001775644,0.00345744,0.0001518491,0.00006454108,0.00005503646],"genre_scores_gemma":[0.9962846,0.001067235,0.0008039467,0.001313808,0.00008643531,0.0002414546,0.0001391486,0.00004703888,0.0000163187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6797906,"threshold_uncertainty_score":0.9999239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988601374111497,"score_gpt":0.2741845428217571,"score_spread":0.2442985290806422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}