{"id":"W2972001191","doi":"10.1021/acschembio.9b00616","title":"Membrane Disruption by Very Long Chain Fatty Acids during Necroptosis","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Biomedical Imaging and Bioengineering; Natural Sciences and Engineering Research Council of Canada; Research Foundation for the State University of New York; University of Michigan; Canada Research Chairs; National Institute of General Medical Sciences; Directorate for Biological Sciences; National Institutes of Health; National Science Foundation","keywords":"Necroptosis; Cell biology; Programmed cell death; Fatty acid; Intracellular; Lipid bilayer; Chemistry; Biochemistry; Membrane; Biophysics; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007495414,0.0002351663,0.0002580498,0.00002991761,0.0000459646,0.00001427695,0.0002665992,0.0004836668,0.0001377826],"category_scores_gemma":[0.00004336458,0.0002010398,0.0001220905,0.00008477303,0.0001188324,0.000006486775,0.000195484,0.0001818102,0.00007347478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000220038,"about_ca_system_score_gemma":0.00002212235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001323501,"about_ca_topic_score_gemma":0.000001827021,"domain_scores_codex":[0.9986607,0.00004523957,0.0002349472,0.0005623923,0.00007995101,0.0004167023],"domain_scores_gemma":[0.9993446,0.00001535976,0.00007543575,0.0004159268,0.0000408855,0.0001077572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135242,0.00004144714,0.03215594,0.00003215596,0.00003655722,0.000001241881,0.00001098336,6.961337e-7,0.9664503,0.00001832619,0.0001196197,0.000997519],"study_design_scores_gemma":[0.0008464088,0.0001132877,0.003367984,0.000007408865,0.00002561542,0.00002735127,0.00001179032,0.000001420673,0.990215,0.000007542466,0.005106612,0.000269559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986584,0.0001364108,0.00004441588,0.000154729,0.0003423263,0.0001939872,0.00004810382,0.00003247666,0.0003891211],"genre_scores_gemma":[0.9973004,0.0001399658,0.0000883399,0.0003042596,0.000381202,0.00002378693,0.001146769,0.00002726793,0.0005879943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02878795,"threshold_uncertainty_score":0.8198167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004965387248227383,"score_gpt":0.2336821865560204,"score_spread":0.228716799307793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}