{"id":"W2972001191","doi":"10.1021/acschembio.9b00616","title":"Membrane Disruption by Very Long Chain Fatty Acids during Necroptosis","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Biomedical Imaging and Bioengineering; Natural Sciences and Engineering Research Council of Canada; Research Foundation for the State University of New York; University of Michigan; Canada Research Chairs; National Institute of General Medical Sciences; Directorate for Biological Sciences; National Institutes of Health; National Science Foundation","keywords":"Necroptosis; Cell biology; Programmed cell death; Fatty acid; Intracellular; Lipid bilayer; Chemistry; Biochemistry; Membrane; Biophysics; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009821931,0.000228386,0.0002298707,0.00008567536,0.0003408738,0.000301255,0.0002588624,0.0004062039,0.001059078],"category_scores_gemma":[0.0001454146,0.0001338372,0.0002595187,0.0001369189,0.0003448751,0.0004387259,0.0002977378,0.0005475208,0.0003225921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005924064,"about_ca_system_score_gemma":0.0003279583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492854,"about_ca_topic_score_gemma":0.001303644,"domain_scores_codex":[0.9999132,0.0000122552,0.000004986618,0.00001977832,0.00003226138,0.00001743345],"domain_scores_gemma":[0.999946,0.000009222897,0.00002136786,0.000005635296,0.000008381574,0.00000946619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009909232,0.0000176518,0.000627138,0.00005983243,0.00001731748,0.0001324253,0.00003410635,0.00406974,0.9928474,0.0009033229,0.00008574025,0.001106314],"study_design_scores_gemma":[0.00002243216,0.0000901086,0.001966914,0.00001426911,0.0000171272,0.0001800002,0.00005232951,0.02251435,0.9712395,0.0008036076,0.003080405,0.00001892551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830154,0.000984506,0.01360041,0.0001527958,0.00003440954,0.00002059135,0.0002635682,0.0001516989,0.001776648],"genre_scores_gemma":[0.9945627,0.0005980938,0.003883473,0.00004698801,0.000002462042,0.00002108542,0.0002033504,0.00001974417,0.000662151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492854,"threshold_uncertainty_score":0.00429827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004965387248227383,"score_gpt":0.2336821865560204,"score_spread":0.228716799307793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}