{"id":"W2972011940","doi":"10.1111/acel.13028","title":"Reversal of epigenetic aging and immunosenescent trends in humans","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":498,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Aging","keywords":"Epigenetics; Biology; Biological age; Demography; Bioinformatics; Genetics; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007634229,0.0001572967,0.0001952298,0.000383454,0.0001204218,0.0002362405,0.0001598848,0.00023468,0.0009943144],"category_scores_gemma":[0.00129663,0.00007996865,0.0001600778,0.0001656861,0.0003450715,0.0002052124,0.0002242194,0.0003026665,0.0001432854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001369618,"about_ca_system_score_gemma":0.0002089484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003367133,"about_ca_topic_score_gemma":0.0004985936,"domain_scores_codex":[0.9997521,0.0001117802,0.00001513095,0.0000555627,0.00005269749,0.00001272272],"domain_scores_gemma":[0.9995885,0.0000982945,0.0001495005,0.00009363793,0.0000449194,0.0000250382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002506934,0.0003111444,0.09868749,0.0003001489,0.0002241766,0.0002392527,0.0004260953,0.001859689,0.7084047,0.003998791,0.0005447602,0.1824968],"study_design_scores_gemma":[0.00009757176,0.007962205,0.528864,0.00005850206,0.0002121426,0.001442166,0.0002589625,0.003406191,0.4375171,0.004090114,0.01603104,0.00005997301],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750997,0.003799416,0.01757663,0.0002479638,0.00006136049,0.00004868252,0.0004303964,0.0001800067,0.00255594],"genre_scores_gemma":[0.9938505,0.0006724744,0.004536921,0.00008675363,0.00001762719,0.0000275573,0.0001022768,0.00001040939,0.0006954291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009943144,"threshold_uncertainty_score":0.00403738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006190921780556469,"score_gpt":0.241716861929878,"score_spread":0.2355259401493215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}