{"id":"W2972011940","doi":"10.1111/acel.13028","title":"Reversal of epigenetic aging and immunosenescent trends in humans","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":498,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Aging","keywords":"Epigenetics; Biology; Biological age; Demography; Bioinformatics; Genetics; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526473,0.00008179276,0.0001030111,0.00007959894,0.0000162432,0.000007831042,0.00006850528,0.00005696612,0.00001973069],"category_scores_gemma":[0.000004463369,0.00008610958,0.00003398607,0.00007594031,0.00002315616,0.000001905895,0.00006211864,0.00004910118,0.000003035887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006855993,"about_ca_system_score_gemma":0.00001203919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008403924,"about_ca_topic_score_gemma":0.0000324322,"domain_scores_codex":[0.999397,0.00003434763,0.0001595615,0.0002075183,0.00006490416,0.0001366344],"domain_scores_gemma":[0.9996796,0.000008003059,0.00006017297,0.0002071911,0.00002006315,0.00002503017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005331131,0.00002147864,0.1562576,0.00002506821,0.000004757168,6.375998e-7,0.000131069,0.0001401184,0.8397015,0.000009022414,0.000009572685,0.003693774],"study_design_scores_gemma":[0.0005168681,0.0001029295,0.1625782,0.00002355398,0.000007930452,3.148435e-7,0.00006990095,0.00006989067,0.8334961,0.0000374413,0.002973849,0.0001230338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924117,0.00460222,0.000161201,0.0000366142,0.00008908669,0.00005449407,0.000001870856,0.000002908901,0.002639891],"genre_scores_gemma":[0.9978845,0.000601379,0.0003295453,0.00002328057,0.00003107641,0.000001371662,0.000030167,0.00001234691,0.001086369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006320558,"threshold_uncertainty_score":0.3511447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006190921780556469,"score_gpt":0.241716861929878,"score_spread":0.2355259401493215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}