{"id":"W2972039360","doi":"10.1016/j.isci.2019.08.057","title":"Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Regina Qu'Appelle Health Region; University of Toronto; University of Saskatchewan; University of Regina","funders":"National Institutes of Health; National Human Genome Research Institute; Scheme for Promotion of Academic and Research Collaboration; Parkinson Society Canada; Vanderbilt University Medical Center; Hospital for Sick Children; Vanderbilt University; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada; Foundation for the National Institutes of Health","keywords":"Neurogenesis; Reprogramming; Induced pluripotent stem cell; Biology; Cell biology; Neurotrophic factors; Cellular differentiation; PINK1; Interactome; Brain-derived neurotrophic factor; Mitochondrion; Stem cell; Neuroscience; Cell; Embryonic stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155584,0.00008194637,0.0001127637,0.00002927649,0.0001119729,0.00001192754,0.0003552573,0.0000585201,0.00001223536],"category_scores_gemma":[0.000216654,0.00005203539,0.00008957004,0.0001793464,0.0002403042,0.000006606722,0.0003643817,0.00007854114,7.530832e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004258099,"about_ca_system_score_gemma":0.00002728196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009214901,"about_ca_topic_score_gemma":0.000007139603,"domain_scores_codex":[0.999034,0.000114185,0.0002287037,0.0003207741,0.0001598759,0.0001423891],"domain_scores_gemma":[0.9991373,0.00001869329,0.0001911717,0.0005764898,0.00004716611,0.00002917562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002227952,0.000008388546,0.09329566,0.00001488841,0.000003217415,1.932542e-7,0.00005497872,0.00002926717,0.9063022,0.00008155956,0.00002240203,0.0001649832],"study_design_scores_gemma":[0.0002197079,0.00008847835,0.2248859,0.00003054909,0.000006994732,0.00002367132,0.00002312338,0.000005782295,0.7732742,0.0000247945,0.001358434,0.0000583135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984419,0.00009859906,0.00001391596,0.00008582966,0.0009722092,0.0002043752,0.000003337187,0.000003620413,0.0001762291],"genre_scores_gemma":[0.9987627,0.000005462261,0.0001125563,0.00008753376,0.0001009952,0.00000393133,5.349199e-7,0.000007363719,0.0009189696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1330279,"threshold_uncertainty_score":0.2121941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044941507188998,"score_gpt":0.2452368044322417,"score_spread":0.2347873893603517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}