{"id":"W2972044339","doi":"10.1038/s41598-019-49163-4","title":"DNA accessibility of chromatosomes quantified by automated image analysis of AFM data","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"German Network for Bioinformatics Infrastructure; Bundesministerium für Bildung und Forschung; Universität Heidelberg; Deutsche Forschungsgemeinschaft","keywords":"Nucleosome; Histone; Linker DNA; DNA; Biophysics; Atomic force microscopy; Chromatin; Chemistry; Computational biology; Biology; Genetics; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003964705,0.0002711425,0.0002828948,0.001105851,0.0002365667,0.000469063,0.0003094188,0.0002586655,0.002277426],"category_scores_gemma":[0.0009365103,0.0001674631,0.0001659812,0.0007174251,0.0001656321,0.0002526392,0.0002538358,0.0003279536,0.0003832567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002906847,"about_ca_system_score_gemma":0.0001789367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046438,"about_ca_topic_score_gemma":0.001543294,"domain_scores_codex":[0.9996158,0.00004752035,0.00003885718,0.00009269599,0.0001576786,0.00004752026],"domain_scores_gemma":[0.9991609,0.0003587181,0.0001064573,0.00008972319,0.000242264,0.00004195972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001338453,0.00003944252,0.002713286,0.0001264375,0.00002815863,0.00006004936,0.0001282237,0.0007994258,0.9692572,0.0003497926,0.0002362846,0.0261279],"study_design_scores_gemma":[0.00001794607,0.0001758728,0.1218625,0.00003011941,0.00005421018,0.0003495941,0.0001756601,0.05751454,0.8163262,0.0004948551,0.002935967,0.00006265319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8831331,0.0007160916,0.109062,0.00007963891,0.00004647858,0.0001271658,0.002587421,0.001421467,0.002826861],"genre_scores_gemma":[0.8944159,0.0006410305,0.09990226,0.00006731923,0.00002770739,0.0002989913,0.002449892,0.0002609819,0.001936015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277426,"threshold_uncertainty_score":0.007618785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107298929967154,"score_gpt":0.2792862829794432,"score_spread":0.2685563899827279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}