{"id":"W2972063248","doi":"10.1016/j.stem.2019.06.013","title":"Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; United States-Israel Binational Science Foundation; New York State Stem Cell Science","keywords":"Genomic imprinting; Biology; Imprinting (psychology); Epigenetics; Embryonic stem cell; Induced pluripotent stem cell; Genetics; Reprogramming; X-inactivation; DNA methylation; Gene; Gene expression; X chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522533,0.0002361468,0.0002681979,0.00005349991,0.00008619592,0.00004382156,0.0001456119,0.0001652506,0.00002609012],"category_scores_gemma":[0.000001391238,0.0002251898,0.00007777246,0.00006225891,0.00006235911,0.000003325888,0.000230536,0.00008808944,0.000008443184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006287331,"about_ca_system_score_gemma":0.0000228126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001087744,"about_ca_topic_score_gemma":0.000005421772,"domain_scores_codex":[0.9986607,0.00007906847,0.0003160426,0.0005091006,0.0001338169,0.0003012815],"domain_scores_gemma":[0.999217,0.00002656184,0.0002369472,0.0003632135,0.00005005579,0.0001061878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005151603,0.0000409118,0.05601779,0.0003330491,0.00001813114,4.562891e-7,0.0000843911,0.00005437464,0.9403462,0.00000290065,0.0000124277,0.003084244],"study_design_scores_gemma":[0.0008917099,0.000423212,0.07147279,0.00003680094,0.000049877,0.0000052044,0.000207246,0.0004635381,0.9258552,0.000007944099,0.0003267018,0.0002597549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936401,0.005169797,0.00009469312,0.000004654085,0.0001223073,0.0003640306,0.00001062199,0.000009604279,0.0005842249],"genre_scores_gemma":[0.9981001,0.0002288368,0.000105425,0.000014484,0.00003974622,0.000007757877,0.00002180384,0.00003728467,0.001444557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.015455,"threshold_uncertainty_score":0.9182975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007473356786152542,"score_gpt":0.2000458829801031,"score_spread":0.1925725261939505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}