{"id":"W2972072194","doi":"10.1007/s12195-019-00597-w","title":"Tissue Targeting and Ultrasound-Targeted Microbubble Destruction Delivery of Plasmid DNA and Transfection In Vitro","year":2019,"lang":"en","type":"article","venue":"Cellular and Molecular Bioengineering","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Science Foundation of Guangdong Province","keywords":"Microbubbles; Transfection; Gene delivery; Biophysics; Molecular biology; Fluorescence microscope; Genetic enhancement; Fluorescein isothiocyanate; Chemistry; Materials science; Biochemistry; Ultrasound; Fluorescence; Biology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006251581,0.0001360136,0.0001622943,0.0001183264,0.00002492055,0.00002109963,0.00003094173,0.00008415072,0.000004599355],"category_scores_gemma":[0.000004485992,0.0001556829,0.00002085852,0.0001239427,0.00002613502,0.00007717468,0.000008876252,0.0001022296,0.000001041226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001510455,"about_ca_system_score_gemma":0.000004046771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002648496,"about_ca_topic_score_gemma":0.000002071959,"domain_scores_codex":[0.9994526,0.00000863585,0.0001596159,0.0001714717,0.00005097323,0.0001567343],"domain_scores_gemma":[0.9998146,0.00002515618,0.00001378826,0.00008266311,0.00001254948,0.00005120221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005281639,0.000005969587,0.0003694226,0.0001930521,0.00001896734,0.00000183308,0.0001860814,0.003918259,0.9938696,0.00004404093,0.000001311536,0.001386155],"study_design_scores_gemma":[0.0003199637,0.00001919665,0.0004555169,0.00002908657,0.00001925059,0.00002882105,0.00009682111,0.01016068,0.9882331,0.00002640903,0.0004468445,0.0001643153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733252,0.004655459,0.02162316,0.000006123958,0.00007796827,0.000178782,0.000007589344,0.00006565705,0.00006005837],"genre_scores_gemma":[0.9972388,0.0005496358,0.002117996,0.000004995828,0.0000141797,0.000009367239,0.00003037202,0.00002963487,0.000005075055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02391354,"threshold_uncertainty_score":0.6348563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002072217823271273,"score_gpt":0.1557859953470047,"score_spread":0.1537137775237334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}