{"id":"W2972107575","doi":"10.1038/s41416-019-0565-8","title":"Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells","year":2019,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"University of Calgary; Cumming School of Medicine, University of Calgary; National Cancer Institute; U.S. Department of Health and Human Services; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Olaparib; Cancer research; Ataxia-telangiectasia; PARP inhibitor; Poly ADP ribose polymerase; Lung cancer; Adenocarcinoma; Cancer; Biology; Molecular biology; Medicine; DNA damage; Pathology; Polymerase; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005062243,0.000516068,0.001113305,0.0004675597,0.0002282642,0.0001777737,0.000213821,0.0003494569,0.003937478],"category_scores_gemma":[0.00004771403,0.0005568534,0.0003816332,0.0007153108,0.0002511567,0.0005612469,0.00007942962,0.00112418,0.00005702641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009286372,"about_ca_system_score_gemma":0.000778002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00234068,"about_ca_topic_score_gemma":0.0001911124,"domain_scores_codex":[0.9958079,0.000210083,0.001400658,0.0006369712,0.001092951,0.000851451],"domain_scores_gemma":[0.9971247,0.0001059386,0.00111143,0.0003550939,0.000668249,0.0006346176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008503275,0.00188872,0.06116693,0.001649795,0.003942841,0.01298291,0.003189628,0.001817653,0.6846778,0.0001122622,0.1267153,0.09335287],"study_design_scores_gemma":[0.07105635,0.003285466,0.0953085,0.01856103,0.002575504,0.02469344,0.001122455,0.003574891,0.7376517,0.0003827898,0.03884742,0.002940456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8516735,0.1421244,0.0001152162,0.001564782,0.002266296,0.0009121346,0.0006448505,0.0001102237,0.0005885512],"genre_scores_gemma":[0.9819114,0.01364224,0.0002242165,0.001547155,0.0007511043,0.00007628068,0.0001364201,0.0001550595,0.001556104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1302379,"threshold_uncertainty_score":0.9996883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006268429481743964,"score_gpt":0.2743134048985936,"score_spread":0.2680449754168496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}