{"id":"W2972122997","doi":"10.1016/j.clbc.2019.08.009","title":"Progression-free Survival Outcome Is Independent of Objective Response in Patients With Estrogen Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Advanced Breast Cancer Treated With Palbociclib Plus Letrozole Compared With Letrozole: Analysis From PALOMA-2","year":2019,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Daiichi Sankyo Europe; Genentech; Daiichi Sankyo Company; Plexxikon; PharmaMar; Eisai; MacroGenics; Amgen; Nippon Kayaku; Astellas Pharma; Mylan; Genomic Health; Novartis Pharma; Novartis; Pfizer; Ontario Brain Institute; Merck; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Palbociclib; Letrozole; Medicine; Breast cancer; Internal medicine; Oncology; Placebo; Metastatic breast cancer; Estrogen receptor; Progression-free survival; Odds ratio; Population; Adverse effect; Cancer; Gynecology; Tamoxifen; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000504741,0.00110309,0.003372206,0.0005526862,0.0001706497,0.00004705692,0.0006458896,0.0004120219,0.002819317],"category_scores_gemma":[0.0001235668,0.0007506729,0.0004750367,0.00232864,0.001065908,0.0006422722,0.0002307196,0.001260052,0.00002194351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001842294,"about_ca_system_score_gemma":0.001048556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005556202,"about_ca_topic_score_gemma":0.001906997,"domain_scores_codex":[0.9921762,0.0009619843,0.001865978,0.001960793,0.001944531,0.001090485],"domain_scores_gemma":[0.9929768,0.001186615,0.001784723,0.001417045,0.001951362,0.0006834178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.196297,0.00118722,0.7900679,0.00007603288,0.004936942,0.00002771162,0.0007360313,0.0004532479,0.0008324634,0.000005223533,0.00001728472,0.005363017],"study_design_scores_gemma":[0.04880533,0.002743051,0.9416853,0.001462553,0.001319537,0.00000936448,0.0008297162,0.00006774623,0.002119677,0.00001025978,0.00002256035,0.0009249426],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982087,0.0002060438,0.0001356828,0.001262599,0.0002013608,0.002631165,0.01328534,0.0001344162,0.00005642586],"genre_scores_gemma":[0.9958948,0.00003664936,0.001937019,0.0004812769,0.0002107879,0.0005236281,0.0005466028,0.0002048176,0.0001644007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1516174,"threshold_uncertainty_score":0.9994944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003432836318951,"score_gpt":0.3391463333567022,"score_spread":0.3191120049935127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}