{"id":"W2972142394","doi":"10.1016/j.chom.2019.08.008","title":"CRISPR-Cas System of a Prevalent Human Gut Bacterium Reveals Hyper-targeting against Phages in a Human Virome Catalog","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"NIH Office of the Director; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Sandler Foundation; Damon Runyon Cancer Research Foundation; Searle Scholars Program; National Institutes of Health; Kinship Foundation; University of California, San Francisco; Burroughs Wellcome Fund","keywords":"Biology; Human virome; CRISPR; Genome; Bacteriophage; Computational biology; Genetics; Human gastrointestinal tract; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000301892,0.0002952836,0.0004590758,0.00008441788,0.0001542894,0.00005820762,0.000442344,0.000135387,0.001968342],"category_scores_gemma":[0.000006766099,0.0002962394,0.0001659778,0.0002060306,0.000121227,0.0003109286,0.000417882,0.0002818806,0.001198847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004391368,"about_ca_system_score_gemma":0.00001051165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136039,"about_ca_topic_score_gemma":0.0001592786,"domain_scores_codex":[0.997992,0.0001149123,0.0006876136,0.0005693976,0.0001384942,0.0004976163],"domain_scores_gemma":[0.9989824,0.00003128189,0.0003422331,0.0005204102,0.00001919288,0.0001044561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001008344,0.0002301552,0.01128853,0.0003384546,0.000009569485,0.00001506002,0.0009731188,0.00002588945,0.9858418,0.000004754797,0.001191823,0.00007078944],"study_design_scores_gemma":[0.0007746955,0.0001457039,0.2268225,0.0004042358,0.00003385154,0.00002663636,0.0006847844,0.00001270885,0.7622823,0.000002274169,0.008382739,0.0004276854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892125,0.000192224,0.00001256993,0.00003357956,0.000317306,0.0006495958,0.00009439994,0.00004909596,0.00943869],"genre_scores_gemma":[0.9939016,0.00002344378,0.0002113797,0.0001146975,0.00005202679,0.00002193543,0.0001077397,0.0000482329,0.005518969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2235595,"threshold_uncertainty_score":0.999949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006424755527041377,"score_gpt":0.2324650978704032,"score_spread":0.2260403423433618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}