{"id":"W2972142394","doi":"10.1016/j.chom.2019.08.008","title":"CRISPR-Cas System of a Prevalent Human Gut Bacterium Reveals Hyper-targeting against Phages in a Human Virome Catalog","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"NIH Office of the Director; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Sandler Foundation; Damon Runyon Cancer Research Foundation; Searle Scholars Program; National Institutes of Health; Kinship Foundation; University of California, San Francisco; Burroughs Wellcome Fund","keywords":"Biology; Human virome; CRISPR; Genome; Bacteriophage; Computational biology; Genetics; Human gastrointestinal tract; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009992527,0.0001638637,0.0002624897,0.0003214399,0.0002975548,0.0004574066,0.0001562117,0.0003600325,0.002698379],"category_scores_gemma":[0.0001572756,0.0001382838,0.0003207065,0.0001945347,0.0001522203,0.000117363,0.0002216728,0.0003858046,0.0006184063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222875,"about_ca_system_score_gemma":0.0002565112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079973,"about_ca_topic_score_gemma":0.001472828,"domain_scores_codex":[0.9998858,0.000008031536,0.000008218385,0.00004263774,0.00003316058,0.00002219235],"domain_scores_gemma":[0.9999216,0.0000193403,0.00001452037,0.00001523037,0.000008249021,0.00002108962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001984807,0.0000172507,0.001221435,0.00003646551,0.00001270418,0.0002590487,0.00002830322,0.0002166192,0.9925389,0.0004822669,0.0003026158,0.004685987],"study_design_scores_gemma":[0.00002281442,0.0002051302,0.02853169,0.00001770839,0.00007201584,0.002416133,0.0001028767,0.008743627,0.9441133,0.0005838807,0.01516082,0.00003008091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802904,0.0006851342,0.01220107,0.0001717522,0.00006903929,0.00002910539,0.002782151,0.0005525658,0.003218838],"genre_scores_gemma":[0.9820552,0.0002901312,0.009566764,0.00009720041,0.000008637301,0.00001642185,0.002754353,0.00008099069,0.005130139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002698379,"threshold_uncertainty_score":0.009027004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006424755527041377,"score_gpt":0.2324650978704032,"score_spread":0.2260403423433618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}