{"id":"W2972161970","doi":"10.1016/j.bbmt.2019.08.029","title":"A Phase 3 Randomized Study of Remestemcel-L versus Placebo Added to Second-Line Therapy in Patients with Steroid-Refractory Acute Graft-versus-Host Disease","year":2019,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Osiris Therapeutics","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Refractory (planetary science); Randomization; Population; Randomized controlled trial; Adverse effect; Gastroenterology; Surrogate endpoint; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002307487,0.001628009,0.003458265,0.0006691633,0.0004987231,0.001027945,0.001035361,0.00167944,0.004468598],"category_scores_gemma":[0.002126378,0.0007681209,0.001771893,0.0004295619,0.001215207,0.001185058,0.000424568,0.003200036,0.0007118247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007464852,"about_ca_system_score_gemma":0.001309998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005854917,"about_ca_topic_score_gemma":0.001838655,"domain_scores_codex":[0.9989838,0.0005844847,0.00005232865,0.0001746346,0.00007066271,0.0001341526],"domain_scores_gemma":[0.9986551,0.0004646642,0.0002852651,0.0001132896,0.00009127034,0.0003903524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9690383,0.01555865,0.0004716454,0.0002616463,0.000511239,0.00004500648,0.0000439186,0.0002841365,0.003604402,0.00007798612,0.0004092194,0.009693779],"study_design_scores_gemma":[0.8686762,0.1291845,0.0009157114,0.00001116585,0.0001657073,0.00002334249,0.00001290918,0.0003646647,0.0003134974,0.00007581353,0.0002451254,0.00001135509],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895583,0.002403043,0.0008236875,0.0005040859,0.000513972,0.004349806,0.0006499634,0.0001331108,0.00106401],"genre_scores_gemma":[0.987474,0.001410409,0.00249858,0.001065614,0.0005554146,0.004584417,0.0006283563,0.00002977467,0.001753582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004468598,"threshold_uncertainty_score":0.0149489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411045428855677,"score_gpt":0.2790744011780713,"score_spread":0.2649639468895145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}