{"id":"W2972180383","doi":"10.1101/gad.328849.119","title":"Regulation of histone methylation by automethylation of PRC2","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Monash University; University of Connecticut; York University; Howard Hughes Medical Institute","keywords":"Biology; PRC2; Histone; Methylation; EZH2; Histone methyltransferase; Genetics; Histone methylation; DNA methylation; Cell biology; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429999,0.0002382146,0.0001391512,0.000145247,0.000151181,0.000253724,0.0002060864,0.0001250371,0.0009643955],"category_scores_gemma":[0.0001377866,0.0001270181,0.0001635752,0.000098168,0.0002303044,0.0001670878,0.0003114476,0.0002156766,0.0003375899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266833,"about_ca_system_score_gemma":0.0001476721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005167833,"about_ca_topic_score_gemma":0.0009118532,"domain_scores_codex":[0.9998468,0.00002624224,0.00001121551,0.00005307958,0.00003457906,0.00002802926],"domain_scores_gemma":[0.9999058,0.00001433235,0.00003008627,0.00001788031,0.00001480934,0.00001712279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004695572,0.000003855022,0.0005108114,0.000009443575,0.000003827949,0.00002053418,0.000007561578,0.000070103,0.9980252,0.0001877441,0.00002186717,0.001092083],"study_design_scores_gemma":[0.00001032187,0.00005612827,0.00906328,0.000001727895,0.00000648487,0.0001087278,0.00001584349,0.001578266,0.9874768,0.0001532909,0.001524541,0.000004637525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914259,0.001169244,0.005360744,0.00008032639,0.00001835118,0.000008670817,0.0001312152,0.0001019315,0.001703666],"genre_scores_gemma":[0.9975119,0.0002200042,0.001027641,0.00002356305,0.000004654287,0.000004770453,0.00009529648,0.000009267355,0.001102997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009643955,"threshold_uncertainty_score":0.003226221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008033147087546186,"score_gpt":0.2740664420629101,"score_spread":0.2660332949753639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}