{"id":"W2972180383","doi":"10.1101/gad.328849.119","title":"Regulation of histone methylation by automethylation of PRC2","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Monash University; University of Connecticut; York University; Howard Hughes Medical Institute","keywords":"Biology; PRC2; Histone; Methylation; EZH2; Histone methyltransferase; Genetics; Histone methylation; DNA methylation; Cell biology; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357398,0.0001082816,0.0001561624,0.00008286977,0.00002548181,0.000003954544,0.00008583866,0.0001246687,0.00005304382],"category_scores_gemma":[0.00002535943,0.0001122228,0.00004624574,0.0001309689,0.00002516497,0.000005423916,0.0000467241,0.00002667508,0.000008774632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002952301,"about_ca_system_score_gemma":0.0001050122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001084579,"about_ca_topic_score_gemma":0.000004945789,"domain_scores_codex":[0.9989618,0.00005061528,0.0004197327,0.0002261705,0.0002269024,0.000114802],"domain_scores_gemma":[0.9992447,0.00001297114,0.0002939759,0.0002287709,0.0001880394,0.0000315343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002932484,0.0000357637,0.01073882,0.00003525492,0.00003123957,1.654383e-8,0.000124301,0.0007109396,0.9406462,0.0000540693,0.00006294357,0.04753115],"study_design_scores_gemma":[0.000273623,0.00009186582,0.07881821,0.00001077194,0.000007123503,1.570784e-7,0.00001661586,0.0001423723,0.8878341,0.0001123674,0.03258023,0.0001125661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802353,0.003568948,0.01511764,0.0000213469,0.0001422255,0.0002418996,0.000005960554,0.000007045537,0.0006596259],"genre_scores_gemma":[0.9868444,0.0003030131,0.01160167,0.000008415424,0.00002611374,0.0000103392,0.0004427775,0.00001560937,0.0007477207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06807938,"threshold_uncertainty_score":0.4576313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008033147087546186,"score_gpt":0.2740664420629101,"score_spread":0.2660332949753639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}