{"id":"W2972184654","doi":"10.3390/cancers11091328","title":"Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Mitacs; Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Neutrophil extracellular traps; Doxorubicin; Pharmacology; Programmed cell death; Idarubicin; NADPH oxidase; Daunorubicin; Medicine; Anthracycline; Inflammation; Immunology; Cancer research; Biology; Cancer; Apoptosis; Leukemia; Internal medicine; Chemotherapy; Oxidative stress; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001812499,0.0002944448,0.0004502696,0.0002014001,0.0001443121,0.00003134622,0.0002769831,0.000234506,0.001027009],"category_scores_gemma":[0.00001084982,0.0002693181,0.00007225428,0.0001534774,0.0001400274,0.0001914608,0.0001476754,0.0003897963,0.0001737808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499739,"about_ca_system_score_gemma":0.0001084596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009732187,"about_ca_topic_score_gemma":0.0004259543,"domain_scores_codex":[0.9982599,0.0001623999,0.0003521829,0.0006128491,0.00006908253,0.0005435913],"domain_scores_gemma":[0.9993314,0.00006703252,0.000125391,0.0003811239,0.00003992357,0.00005519047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190103,0.00003612526,0.009119343,0.00003455966,0.00007524215,0.00003216898,0.0002243568,0.0001466114,0.9874579,0.001472091,0.000414274,0.0008682735],"study_design_scores_gemma":[0.004675322,0.0004686483,0.04072811,0.0001330665,0.00005173379,0.00005682289,0.0007909038,0.00001705826,0.9424222,0.0004893389,0.009556149,0.0006107023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950879,0.001892567,0.00001660565,0.0002227249,0.0008643497,0.0004830137,0.00004360754,0.00005547259,0.001333805],"genre_scores_gemma":[0.9970421,0.0003485458,0.00002750837,0.000456866,0.00005551492,0.00005942369,0.00005792952,0.00003459815,0.001917525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0450358,"threshold_uncertainty_score":0.9999759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160772441668362,"score_gpt":0.248710639523492,"score_spread":0.2371029151068083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}