{"id":"W2972184654","doi":"10.3390/cancers11091328","title":"Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Mitacs; Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Neutrophil extracellular traps; Doxorubicin; Pharmacology; Programmed cell death; Idarubicin; NADPH oxidase; Daunorubicin; Medicine; Anthracycline; Inflammation; Immunology; Cancer research; Biology; Cancer; Apoptosis; Leukemia; Internal medicine; Chemotherapy; Oxidative stress; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008184265,0.0001877897,0.0001855701,0.00008075459,0.00007131693,0.00009127205,0.00007481255,0.00009909242,0.0009620695],"category_scores_gemma":[0.00009489073,0.00004576727,0.0001278417,0.0000535095,0.00006375444,0.0000689654,0.00008551082,0.0002300573,0.0001999136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008189324,"about_ca_system_score_gemma":0.0001245336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003591861,"about_ca_topic_score_gemma":0.0007763337,"domain_scores_codex":[0.9999266,0.00001856393,0.000009564043,0.00001271252,0.00001694607,0.0000157406],"domain_scores_gemma":[0.9999564,0.000008636976,0.00001091195,0.000005275409,0.000007161439,0.00001163621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008297982,0.0001605068,0.0003860633,0.00009715957,0.00000800833,0.0000608552,0.00002102622,0.00008037561,0.9926164,0.00005151943,0.0002363371,0.005451783],"study_design_scores_gemma":[0.0001968815,0.003606684,0.01133351,0.00001438493,0.00002815316,0.0004036413,0.00003504469,0.0006877091,0.9768489,0.00004441058,0.006794902,0.000005704201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927374,0.004197971,0.0009590164,0.0001380153,0.00005998341,0.00005321447,0.0003727747,0.00003741625,0.001444133],"genre_scores_gemma":[0.9939119,0.002286068,0.0009014916,0.00008246909,0.00002174913,0.00003318536,0.0007488606,0.000005999178,0.002008317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009620695,"threshold_uncertainty_score":0.003218472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160772441668362,"score_gpt":0.248710639523492,"score_spread":0.2371029151068083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}