{"id":"W2972185762","doi":"10.1017/cjn.2019.257","title":"Stereologic measures of beta-amyloid load in postmortem autosomal dominant Alzheimer disease brain validate PiB-PET as a useful biomarker","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pathology; Positron emission tomography; Biomarker; Pittsburgh compound B; Amyloidosis; Amyloid (mycology); Medicine; Amyloid beta; Alzheimer's disease; Nuclear medicine; Senile plaques; Disease; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004115853,0.0003756866,0.0002347342,0.001070562,0.0002066805,0.000227496,0.0001698046,0.0002081336,0.001488155],"category_scores_gemma":[0.0005293011,0.0002095841,0.0001402939,0.0003151847,0.000339851,0.0002196531,0.0001999641,0.0002903568,0.0003389043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619415,"about_ca_system_score_gemma":0.0001301492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001616497,"about_ca_topic_score_gemma":0.003616876,"domain_scores_codex":[0.9997997,0.00003131097,0.00002428234,0.00005505664,0.0000688061,0.00002094539],"domain_scores_gemma":[0.9996328,0.00005183009,0.000102357,0.0000859086,0.00009456897,0.00003247468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003687998,0.0001486474,0.02479475,0.00006663728,0.0000437361,0.00024931,0.0002706271,0.0003055097,0.9581468,0.0001865642,0.0002232811,0.01519528],"study_design_scores_gemma":[0.00006042438,0.00067451,0.7845522,0.00001913715,0.00004476198,0.003205251,0.0002477071,0.003890828,0.2047503,0.0007686085,0.001764448,0.00002181828],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837462,0.0008742228,0.01207935,0.00003637497,0.00001631046,0.00006651897,0.000847658,0.0002570197,0.002076367],"genre_scores_gemma":[0.9853647,0.0003922383,0.01174315,0.00003218478,0.0000085663,0.00007202566,0.0008588353,0.00008138135,0.001446884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001616497,"threshold_uncertainty_score":0.004978359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07196655295236931,"score_gpt":0.3192284060220464,"score_spread":0.2472618530696771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}