{"id":"W2972188181","doi":"10.1111/cbdd.13618","title":"Synthesis, antiproliferative activity, and molecular docking studies of 4‐chlorothiocolchicine analogues","year":2019,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Allard Foundation; Narodowe Centrum Nauki","keywords":"Colchicine; Cytotoxicity; Doxorubicin; Cisplatin; Chemistry; In silico; Docking (animal); In vitro; Cell culture; Pharmacology; Tubulin; Stereochemistry; Cytotoxic T cell; Antimitotic Agent; Biochemistry; Biology; Chemotherapy; Microtubule; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006751365,0.0003463716,0.000320909,0.0001598398,0.0001062045,0.0001188803,0.0002361709,0.0001551906,0.001711751],"category_scores_gemma":[0.0001051329,0.000100703,0.0002149175,0.0002397872,0.000108242,0.0001121999,0.0001005783,0.0002765979,0.0003421959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639959,"about_ca_system_score_gemma":0.0001738796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00159365,"about_ca_topic_score_gemma":0.00225673,"domain_scores_codex":[0.9999543,0.000008958211,0.00000361396,0.000009628555,0.00001080996,0.00001269209],"domain_scores_gemma":[0.9999477,0.000007075393,0.00001610617,0.000004401875,0.00001072608,0.00001402026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003698274,0.00006551133,0.0002088504,0.0002920064,0.00002649955,0.0002536216,0.00003794188,0.003840226,0.9894964,0.0002280929,0.0002839737,0.004897049],"study_design_scores_gemma":[0.00009453867,0.002125221,0.002280265,0.00002154176,0.000063427,0.0004071604,0.00004887629,0.005036925,0.9815732,0.00005331511,0.008263136,0.00003240232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985845,0.004029438,0.003894029,0.0001083418,0.00004529947,0.00009345602,0.001165009,0.0001159139,0.004703577],"genre_scores_gemma":[0.9883619,0.003472103,0.004692818,0.00003983597,0.000009926971,0.00004467279,0.001087409,0.00002404237,0.002267421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711751,"threshold_uncertainty_score":0.005726397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03614883454742611,"score_gpt":0.2889074135796491,"score_spread":0.2527585790322229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}