{"id":"W2972188181","doi":"10.1111/cbdd.13618","title":"Synthesis, antiproliferative activity, and molecular docking studies of 4‐chlorothiocolchicine analogues","year":2019,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Allard Foundation; Narodowe Centrum Nauki","keywords":"Colchicine; Cytotoxicity; Doxorubicin; Cisplatin; Chemistry; In silico; Docking (animal); In vitro; Cell culture; Pharmacology; Tubulin; Stereochemistry; Cytotoxic T cell; Antimitotic Agent; Biochemistry; Biology; Chemotherapy; Microtubule; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820626,0.0002754413,0.0007893529,0.00004132804,0.00004868701,0.000009930275,0.0002154616,0.0002683167,0.0001529396],"category_scores_gemma":[0.0008040091,0.0001859331,0.0001150076,0.00009890367,0.0005151549,0.00005780801,0.0002079709,0.000245669,0.00001153257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000342362,"about_ca_system_score_gemma":0.00002240378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000146934,"about_ca_topic_score_gemma":6.312903e-7,"domain_scores_codex":[0.9986045,0.0001615735,0.0002740179,0.0005523961,0.00009685254,0.0003106173],"domain_scores_gemma":[0.9969804,0.00239563,0.0001938848,0.0002685426,0.00008898172,0.00007253184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001945133,0.0001313555,0.01417567,0.0001164306,0.0002401543,0.000003776274,0.00007551105,0.000001828864,0.9793257,0.0001860592,0.00004750815,0.005501488],"study_design_scores_gemma":[0.000249576,0.00004646234,0.0003346924,0.0001094834,0.00005772088,0.000006619686,0.0001277285,0.0001054375,0.9970313,0.001613612,0.00009171639,0.0002256379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965975,0.001669408,0.0001201009,0.0003315641,0.00003383584,0.0001881896,0.00002054656,0.00005494933,0.0009838785],"genre_scores_gemma":[0.9989077,0.0003063131,0.0005428242,0.00008869007,0.00005924835,0.00005378797,0.000005655003,0.00001353167,0.00002226486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0177056,"threshold_uncertainty_score":0.7582133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03614883454742611,"score_gpt":0.2889074135796491,"score_spread":0.2527585790322229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}