{"id":"W2972220587","doi":"10.1002/mc.23106","title":"p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cancer research; Downregulation and upregulation; Gene silencing; Hexokinase; Reprogramming; Regulator; Transcription factor; Protein kinase B; Ovarian cancer; Cancer cell; Cell growth; Gene knockdown; Warburg effect; Cell biology; Glycolysis; Cancer; Signal transduction; Apoptosis; Cell; Gene; Metabolism; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005900169,0.0001489489,0.0001254263,0.0001981872,0.0001226284,0.0002629942,0.00006967941,0.0001266863,0.001132521],"category_scores_gemma":[0.00009432714,0.00008965352,0.0001621922,0.0001635427,0.000142493,0.0001499204,0.0001418913,0.000275266,0.0001542277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259252,"about_ca_system_score_gemma":0.0001544081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004902575,"about_ca_topic_score_gemma":0.0006234958,"domain_scores_codex":[0.9999423,0.00000680246,0.000005221106,0.00001529554,0.00001258088,0.00001774183],"domain_scores_gemma":[0.999969,0.00000361311,0.00001108293,0.000003511384,0.000005151766,0.000007636928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002393077,0.00003467682,0.003602863,0.00007698315,0.000008612585,0.0001701628,0.00004011618,0.000140231,0.9902771,0.0002571573,0.000137192,0.005015611],"study_design_scores_gemma":[0.00004352564,0.0004238804,0.09089286,0.00001670698,0.00004909023,0.0005620681,0.0001831872,0.002849966,0.8976721,0.0003806276,0.00691685,0.000009071968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993186,0.002958538,0.001900802,0.0001536573,0.0000399683,0.0000208275,0.0002971789,0.00009463064,0.001348461],"genre_scores_gemma":[0.9979206,0.0008026079,0.0002839129,0.00003159832,0.000004618448,0.00001516876,0.0001604842,0.00000500585,0.000775947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132521,"threshold_uncertainty_score":0.00378865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007385682564394864,"score_gpt":0.2297289185805192,"score_spread":0.2223432360161244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}