{"id":"W2972220587","doi":"10.1002/mc.23106","title":"p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cancer research; Downregulation and upregulation; Gene silencing; Hexokinase; Reprogramming; Regulator; Transcription factor; Protein kinase B; Ovarian cancer; Cancer cell; Cell growth; Gene knockdown; Warburg effect; Cell biology; Glycolysis; Cancer; Signal transduction; Apoptosis; Cell; Gene; Metabolism; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003746194,0.0003239321,0.0004116588,0.0001255001,0.0001183677,0.00004252998,0.0001803482,0.0002399927,0.00002040987],"category_scores_gemma":[0.0000545421,0.0003451118,0.000170089,0.0002760415,0.00007522861,0.000013518,0.0001258871,0.0001111307,0.000001670525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002844679,"about_ca_system_score_gemma":0.0001329981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007942207,"about_ca_topic_score_gemma":0.0001343338,"domain_scores_codex":[0.9979051,0.0001697485,0.0003444364,0.0008564492,0.0002385559,0.0004856554],"domain_scores_gemma":[0.9990854,0.000007671558,0.0001190069,0.0005425977,0.0001059303,0.0001394076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002458679,0.00006063024,0.006364685,0.00005480403,0.00007422012,0.000006254489,0.0002118299,0.00009758487,0.9641259,0.00004229578,0.00002723697,0.02868874],"study_design_scores_gemma":[0.001731,0.0001045695,0.015745,0.00003095341,0.0001036241,0.00003099071,0.00006425134,0.0001061026,0.956539,0.00002595901,0.02511294,0.0004055835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567222,0.04124216,0.0006245704,0.0001889347,0.0004590839,0.0006145459,0.00008084851,0.00002224536,0.00004538742],"genre_scores_gemma":[0.9960452,0.001346217,0.001179493,0.0003008628,0.0003698599,0.000184379,0.0001473965,0.00007419939,0.0003524149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03989595,"threshold_uncertainty_score":0.9999001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007385682564394864,"score_gpt":0.2297289185805192,"score_spread":0.2223432360161244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}