{"id":"W2972226121","doi":"10.1016/j.tips.2019.08.005","title":"Towards Targeting the Urotensinergic System: Overview and Challenges","year":2019,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique; Armand Frappier Museum","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Urotensin-II; Heart failure; Antagonist; In vivo; Medicine; Pharmacology; Receptor; Computational biology; Bioinformatics; Biology; Internal medicine; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000934333,0.0008318278,0.001724144,0.001317787,0.0002136415,0.001458004,0.0009015386,0.001204309,0.00292498],"category_scores_gemma":[0.0007697546,0.0002416419,0.0005468086,0.00116745,0.000463215,0.001739015,0.0008052955,0.002672495,0.001366197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004591661,"about_ca_system_score_gemma":0.001325539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006296295,"about_ca_topic_score_gemma":0.001651473,"domain_scores_codex":[0.9998057,0.00003462684,0.00002962446,0.00004262254,0.00006336662,0.00002388355],"domain_scores_gemma":[0.9995301,0.000237682,0.00005212962,0.00001327426,0.0001157488,0.00005107767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002087156,0.0001462725,0.0003096231,0.0244231,0.0001692923,0.0002494147,0.00005508084,0.0004034471,0.004915871,0.00559638,0.01903358,0.9444892],"study_design_scores_gemma":[0.00004771755,0.0002825531,0.001217,0.006212714,0.0002875043,0.001193565,0.0001261431,0.0002752867,0.001068013,0.004803341,0.9844536,0.00003259542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001196114,0.998654,0.0001950388,0.0004658919,0.0001841759,0.000002379754,0.00001244598,0.000005927386,0.0003605755],"genre_scores_gemma":[0.0005221253,0.9984125,0.0002824673,0.0002684632,0.0002453108,0.000004213089,0.00001794583,0.000001154005,0.0002458399],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00292498,"threshold_uncertainty_score":0.009785056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4316856338100805,"score_gpt":0.4767664756007905,"score_spread":0.04508084179071004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}