{"id":"W2972256509","doi":"10.1007/s40257-019-00466-2","title":"Efficacy, Safety, and Patient-Reported Outcomes in Patients with Moderate-to-Severe Plaque Psoriasis Treated with Brodalumab for 5 Years in a Long-Term, Open-Label, Phase II Study","year":2019,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bausch Health; Ortho Dermatologics; AstraZeneca; Amgen","keywords":"Medicine; Dermatology Life Quality Index; Psoriasis Area and Severity Index; Tolerability; Psoriasis; Adverse effect; Internal medicine; Quality of life (healthcare); Dermatology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002907011,0.0008567766,0.001519293,0.0002884596,0.0004305874,0.0008044415,0.0005107754,0.0008776853,0.001248354],"category_scores_gemma":[0.001278046,0.0003944431,0.001637756,0.0002602065,0.0004683986,0.0005354946,0.0002600674,0.00183248,0.0002996501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990598,"about_ca_system_score_gemma":0.0005333793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002912901,"about_ca_topic_score_gemma":0.0005233695,"domain_scores_codex":[0.9992477,0.0003792933,0.0000618094,0.0001022259,0.0001185875,0.00009038345],"domain_scores_gemma":[0.9985332,0.0002876564,0.0005264427,0.0001048629,0.0001034497,0.0004443292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6936445,0.06981485,0.1118367,0.001149182,0.004523151,0.0004412241,0.000453472,0.001689423,0.03351721,0.00007427028,0.00121445,0.08164153],"study_design_scores_gemma":[0.2087921,0.5029227,0.2805751,0.0000669975,0.001571036,0.0005688154,0.000109825,0.001720477,0.002438504,0.00006736795,0.001109702,0.00005735936],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982174,0.0009898504,0.0001088617,0.00004962502,0.00001786566,0.0002231028,0.0001110141,0.0000108242,0.0002713883],"genre_scores_gemma":[0.9981997,0.0003775416,0.0003007319,0.0001764835,0.00006620664,0.0002896816,0.00031601,0.000002743328,0.0002709292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002907011,"threshold_uncertainty_score":0.01537389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02576492886336649,"score_gpt":0.3379926812463918,"score_spread":0.3122277523830253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}