{"id":"W2972289446","doi":"10.1016/j.jtho.2019.08.2503","title":"Impact of Specimen Characteristics on PD-L1 Testing in Non–Small Cell Lung Cancer: Validation of the IASLC PD-L1 Testing Recommendations","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Université Laval; Montreal Heart Institute","funders":"AstraZeneca","keywords":"Medicine; Lung cancer; Internal medicine; Oncology; PD-L1; Cancer; Biopsy; Immunohistochemistry; clone (Java method); Pathology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05093771,0.0007070893,0.001068814,0.001773031,0.0007892757,0.003612922,0.002238617,0.001712836,0.002632569],"category_scores_gemma":[0.1150291,0.0004952038,0.001555077,0.001212256,0.001131946,0.002054937,0.001409729,0.002359288,0.001510577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001629503,"about_ca_system_score_gemma":0.002608119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002651078,"about_ca_topic_score_gemma":0.00614014,"domain_scores_codex":[0.977025,0.009169598,0.003726331,0.001764326,0.007706678,0.0006078962],"domain_scores_gemma":[0.8902308,0.0721162,0.00811699,0.00840391,0.01899278,0.00213926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003248564,0.0002952169,0.593201,0.001504945,0.0009383247,0.000437493,0.000727023,0.004344564,0.005674654,0.002472834,0.04649255,0.3406628],"study_design_scores_gemma":[0.0005563286,0.005160597,0.6647428,0.00479237,0.002470557,0.004639843,0.001831482,0.02662739,0.03972685,0.009171648,0.2400637,0.0002164044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7256317,0.05093646,0.04778245,0.07831912,0.006039305,0.001769874,0.01334376,0.001441012,0.0747363],"genre_scores_gemma":[0.9270142,0.003533499,0.0431537,0.01466813,0.001185216,0.0005423692,0.006451377,0.0003796681,0.003071868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05093771,"threshold_uncertainty_score":0.2693876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04424345787969483,"score_gpt":0.4129967866273894,"score_spread":0.3687533287476946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}