{"id":"W2972303634","doi":"10.1093/molbev/msz200","title":"Can the RNA World Still Function without Cytidine?","year":2019,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Compute Canada","keywords":"Biology; RNA; Genetics; RNA world hypothesis; Sequence (biology); Cytosine; Ribozyme; Base pair; Computational biology; Alphabet; Pairing; DNA; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120946,0.000105526,0.0001069955,0.00005107157,0.0001163026,0.0000145295,0.00006441904,0.00004406131,0.0002070971],"category_scores_gemma":[0.000002519258,0.00007404712,0.0000525972,0.0001165132,0.00007590444,0.00004086423,0.0000349093,0.0001297206,0.00007083056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002339888,"about_ca_system_score_gemma":0.00002915001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003275816,"about_ca_topic_score_gemma":0.0000304054,"domain_scores_codex":[0.9993875,0.00006615071,0.0001119608,0.0001978894,0.0000491291,0.000187346],"domain_scores_gemma":[0.9996833,0.00001403447,0.00005761736,0.0001703503,0.00003266281,0.00004210283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003460143,0.0000227591,0.5349117,0.000003666226,0.0000598463,1.641197e-7,0.00002801167,0.00009956243,0.01744853,0.4453816,0.0007699343,0.001239688],"study_design_scores_gemma":[0.002357489,0.0005029818,0.5490071,0.00004524866,0.0001936277,0.000006200769,0.000413199,0.00548778,0.004086869,0.2257518,0.2113833,0.0007643563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961188,0.0002810541,0.02800218,0.001119221,0.0004594554,0.000172558,0.00002286602,0.00002718857,0.008727432],"genre_scores_gemma":[0.9979272,0.000002049039,0.00007311762,0.0001884118,0.0001847101,0.00001248646,0.00004974293,0.000007554241,0.001554728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2196297,"threshold_uncertainty_score":0.3019554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004549528750062059,"score_gpt":0.231442484483052,"score_spread":0.22689295573299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}