{"id":"W2972305135","doi":"10.1101/758607","title":"Ethanol stress stimulates sumoylation of transcription factor Cst6 which restricts expression of its target genes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research","keywords":"SUMO protein; Chromatin immunoprecipitation; Transcription factor; Biology; Mutant; Cell biology; Transcription (linguistics); Saccharomyces cerevisiae; Chromatin; Promoter; Gene expression; Gene; Genetics; Ubiquitin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006042815,0.000273813,0.0002419586,0.0001353402,0.0001021991,0.0002140922,0.000129188,0.0001384089,0.001751812],"category_scores_gemma":[0.00006152204,0.0001318776,0.0003069031,0.0001493568,0.0001490733,0.0001173481,0.000228219,0.0003994862,0.0005701432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668613,"about_ca_system_score_gemma":0.00009345786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005162046,"about_ca_topic_score_gemma":0.0006310396,"domain_scores_codex":[0.9999036,0.000009544662,0.00001232661,0.00002887256,0.00002488375,0.00002083724],"domain_scores_gemma":[0.9998963,0.00001565393,0.00002439546,0.00001583545,0.00001518567,0.00003266105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004484341,0.000006261937,0.0001163126,0.00001109662,0.000001604874,0.00000839807,0.000002264932,0.00001099893,0.9995871,0.00001386977,0.00001275897,0.0001845879],"study_design_scores_gemma":[0.000005409039,0.00007314554,0.007804724,0.000003499927,0.000006013337,0.00007838709,0.00002056113,0.0005380665,0.9903693,0.00002641618,0.001072117,0.000002297599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940025,0.001178972,0.002749857,0.0000873644,0.00003579483,0.00001308531,0.0008716406,0.00007419119,0.0009865445],"genre_scores_gemma":[0.9920093,0.0005708847,0.00154351,0.0000671688,0.00001083114,0.00001847427,0.002106199,0.00002887651,0.00364465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751812,"threshold_uncertainty_score":0.005860388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947121412891104,"score_gpt":0.2336434890644178,"score_spread":0.2141722749355068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}