{"id":"W2972356256","doi":"10.1016/j.ijpara.2019.05.012","title":"The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus","year":2019,"lang":"en","type":"article","venue":"International Journal for Parasitology","topic":"Helminth infection and control","field":"Veterinary","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; Harvey L. Neiman Health Policy Institute; Department for Environment, Food and Rural Affairs, UK Government; Scottish Government; Scottish Funding Council; Wellcome Trust; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Biology; Haemonchus contortus; Genetics; Gene; Single-nucleotide polymorphism; Genetic variation; Population; Phenotype; Nematode; Genotype; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003018772,0.000218293,0.000312778,0.000764047,0.000811509,0.0008047801,0.0002797839,0.0004040256,0.0006002028],"category_scores_gemma":[0.005383097,0.0002220553,0.0002379845,0.0007889877,0.001279033,0.0003213765,0.0007601308,0.0006634298,0.0001809475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291728,"about_ca_system_score_gemma":0.000222448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009232453,"about_ca_topic_score_gemma":0.004045302,"domain_scores_codex":[0.9948599,0.002684993,0.0003298322,0.0009886171,0.0008810855,0.0002555895],"domain_scores_gemma":[0.9948598,0.003228026,0.0006346154,0.0006041773,0.0005164922,0.0001568825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003495065,0.00009503068,0.08071569,0.0001420126,0.0001592593,0.0002890735,0.0006192966,0.001093974,0.8945563,0.001424303,0.0002029598,0.02035267],"study_design_scores_gemma":[0.00001964851,0.0003200537,0.7564115,0.00003801618,0.0001090872,0.001545784,0.0003943543,0.007693889,0.2278417,0.003190133,0.002397012,0.00003885526],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962166,0.0004726847,0.03399588,0.0002109929,0.00006837367,0.00005053603,0.0003499572,0.00005202398,0.002633589],"genre_scores_gemma":[0.9856777,0.0001273025,0.01283559,0.0002727285,0.00005371822,0.00007122137,0.0002493972,0.0000472564,0.0006650915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003018772,"threshold_uncertainty_score":0.01596493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823897816172458,"score_gpt":0.3495836690228092,"score_spread":0.3313446908610846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}