{"id":"W2972397981","doi":"10.1002/mgg3.956","title":"Metformin treatment in young children with fragile X syndrome","year":2019,"lang":"en","type":"article","venue":"Molecular Genetics & Genomic Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Intellectual and Developmental Disabilities Research Center; U.S. Department of Health and Human Services; National Institutes of Health; Azrieli Foundation; National Center for Advancing Translational Sciences","keywords":"Metformin; Lethargy; Fragile X syndrome; Irritability; Medicine; Novelty; Type 2 diabetes; Pediatrics; Psychiatry; Cognition; Diabetes mellitus; Psychology; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220701,0.000308172,0.0006462245,0.0004252645,0.0007250938,0.0002641779,0.0001813358,0.0006305487,0.0008440872],"category_scores_gemma":[0.0009097214,0.0001204903,0.000373909,0.0003560382,0.0002722556,0.0001727688,0.0002938826,0.000593816,0.0001181257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000676145,"about_ca_system_score_gemma":0.0008108848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002805318,"about_ca_topic_score_gemma":0.006748827,"domain_scores_codex":[0.9998581,0.00003078133,0.00002251296,0.00001884394,0.00002955174,0.00004017891],"domain_scores_gemma":[0.9996462,0.00008175837,0.0001282777,0.000007075108,0.00001923907,0.0001175325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006203546,0.001786483,0.7596289,0.0009203529,0.0003897834,0.09912545,0.001509106,0.0004009148,0.01627964,0.0005384774,0.005260041,0.1079572],"study_design_scores_gemma":[0.0009744542,0.01098325,0.8462545,0.0005386504,0.0004514082,0.1168002,0.001568738,0.0002823154,0.00549911,0.0003431083,0.01625155,0.000052659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878227,0.008654128,0.0001235054,0.0006372666,0.00008058329,0.00009076508,0.0002871874,0.00002640991,0.002277454],"genre_scores_gemma":[0.9925466,0.004862086,0.0008635371,0.0006328573,0.00005577491,0.0001368149,0.0003990345,0.000005516022,0.000497801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002805318,"threshold_uncertainty_score":0.005577922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004266052290151031,"score_gpt":0.2067639379528761,"score_spread":0.2024978856627251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}